DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snama and rbbp6

DIOPT Version :9

Sequence 1:	NP_611884.1	Gene:	snama / 37857	FlyBaseID:	FBgn0086129	Length:	1231	Species:	Drosophila melanogaster
Sequence 2:	NP_001180603.1	Gene:	rbbp6 / 445396	ZFINID:	ZDB-GENE-040930-5	Length:	1766	Species:	Danio rerio

Alignment Length:	1833	Identity:	443/1833 - (24%)
Similarity:	653/1833 - (35%)	Gaps:	690/1833 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VHYKFKSTLNFDTITFDGLHISVGDLKREIVQQKRLGKIIDFDLQITNAQSKEEYKDDGFLIPKN 67
            |||||.|.||:||:|||||||::.||||:|:.:::| |..|.||||||||:||||.||..|||||
Zfish     4 VHYKFSSKLNYDTVTFDGLHITLSDLKRQIMGREKL-KAADCDLQITNAQTKEEYTDDEALIPKN 67

  Fly    68 TTLIISRIPIA--HPTKKGW-----EPPAAENAFSAAP------AKQDNFNMDLSKMQGTEEDKI 119
            :::||.||||.  ..|.|.:     ||..:..|..::.      :|..|    |::...:|||||
Zfish    68 SSVIIRRIPIGGLKSTSKTYVIDRSEPSGSSKAIDSSSISLALLSKTAN----LAETNASEEDKI 128

  Fly   120 QAMMMQSTVDYDPKTYHRIKGQSQVGEVPASYRCNKCKKSGHWIKNCPFVGGKDQ-----QEVKR 179
            :|||.||..||||..|    .:..||..|.:|.|.:|.|:||:|:||| ..|:|:     |.:|:
Zfish   129 KAMMSQSNHDYDPIHY----AKKLVGPPPPNYTCFRCGKTGHYIRNCP-TNGQDRSFEAPQRIKK 188

  Fly   180 NTGIPRSFRDKPDAAENE------SADFVLPAV-----------------QNQE--------IPE 213
            :|||||||..:.|....:      |..:.:|.:                 |||.        :|:
Zfish   189 STGIPRSFMVEVDDPNRKGVMLTNSGIYAIPTIDAEAYAIGKKEKPPFLPQNQSSSSEEEDPVPD 253

  Fly   214 DLICGICRDIFVDAVMIPCCGSSFCDDCVRTSLLESEDSECPDCKEKNCSPGSLIPNRFLRNSVN 278
            :|:|.||:|:..|||:|||||:|:||||:||.|||||:..||.||:.:.||.:||.|:|||.:||
Zfish   254 ELLCLICKDLMTDAVVIPCCGNSYCDDCIRTCLLESEEHVCPTCKQSDVSPDALIANKFLRQAVN 318

  Fly   279 AFKNETGYNKSAAKPAAVK----------NEEKPPVEKE-------VEKKPVAEVEPEETEVKPE 326
            .|||||||.|...|..|.:          ..::||:.::       |.........|:.|...|.
Zfish   319 NFKNETGYTKRIRKATATQAVAQGAQKQAPAQRPPMRRQQDPLIPSVPSSAADSTPPQSTPAAPL 383

  Fly   327 KQKESETNGSNPPKSESPEPPATTEPSQKEKDKYDSDY------------EDNITIKMPQPAADS 379
            ....:....|.||.|.|....::|.|:       .|:|            :|:     |.|:.:.
Zfish   384 SPVSTHEPSSTPPSSSSSTVHSSTAPA-------GSNYSPVVNSPPHPTRQDD-----PPPSKEP 436

  Fly   380 TTVPSKRSPSYSHRSESSHRRDRSDY----------VSDHDHK-------HQRPSKSES------ 421
            .|.||...|| |..|.|::......|          ...|.|:       .||||.|.|
Zfish   437 ETPPSAVIPS-SETSMSTNSAVPKGYHVPVIGKPSLPQQHMHRPGPQRSSGQRPSGSRSGWDPST 500

  Fly   422 ----VNKDR--SLLPLPIGTLPSYQGHMMAESEEARRSSAYKPPYMQMQRGPPPMHMMSHHMPAY 480
                :..:|  .:.|.|:..||                ....|.::.....|||.|.|
Zfish   501 SRGRLQSERPPRIQPQPVQNLP----------------PVVPPVFVPPALFPPPPHPM------- 542

  Fly   481 NNGFNNMGQRPPLSYVPYQNQSVHPMRAPYGSAGGGMNMNMSQPFQSPNLASIYQGVAAKVGSG- 544
                    .:||: .|..|    :|::.|.|......:.|:..|...|...::   .|..|..|
Zfish   543 --------PQPPV-VVSQQ----YPIQFPQGQQPPPPSFNIPPPVFPPVPPNV---TAPWVPPGP 591

  Fly   545 --PIDDPLEAF--------------NRIMKE--------KERKKVDRF----------------- 568
              ||.:|:.|.              .|.:||        :|:.|::.|
Zfish   592 QPPIANPISAMPAAPFLSKEEFYRQQRRLKEDSQCRFVTREKSKLEEFTNDFAKELLEYRKIQKE 656

  Fly   569 RSSDRHRSRSP-------------DRQRHRFKSP-MYEKDNSRDNLKDKRPRSRERKREHSYER- 618
            |.....||:||             .:.|.|.:|| .|.:..||..   .|.|||.|.|..|:.|
Zfish   657 RRRSYSRSKSPYRGSSYSGSSYSYSKSRSRSRSPRSYSRSLSRSR---SRSRSRSRSRSRSFSRS 718

  Fly   619 -HIRHPRS--------SRQP---NDGSKSPGGRIKR-----SGHRRSASPKPGYKS--------- 657
             :.|.||.        ||.|   ...|:||..|.:.     ||..||.|..|.|::
Zfish   719 PYSRRPRGRSRSYRSRSRTPTFHRSRSRSPSYRGREMSGMVSGIYRSRSRSPMYRNHSPGKKLPP 783

  Fly   658 ----------------------------------------------DYRD------KPYNKPS-- 668
                                                          :||:      |.||.|.
Zfish   784 PAQLEGERKYTGRYRELPPYDAKAYYGRNVDQSDPYERERYREWEREYREWYDKYFKNYNNPPSG 848

  Fly   669 ------------------AP------------KTEAVEPPPPGF--------------------- 682
                              ||            :.|...|||...
Zfish   849 QMRSRVPGSRDAYSPERFAPPRPRENSPYNRGRREDYPPPPQSHSAQSRGRVAMTYQEKCAEKFG 913

  Fly   683 ---------------EPLQ-----------LTD--------------EDGYRNKHPTSSEASQ-- 705
                           |||:           .||              |||....|..|.:.|:
Zfish   914 HLHANTTGTGRSLNKEPLKPIKDREQSGNSATDSKSLKHKKHRKKKREDGDLFSHSDSMDESRKD 978

  Fly   706 ----------SSKGDSSKKRGE-----------------------------NRHEEAPRKRHRSR 731
                      ||:.|::..|.|                             .:.|.:.:|:..|.
Zfish   979 DRKMDSMLINSSRDDATPVRDEPMDGAAVPYKRTPEKEKKEKTKSKSEKVKRKSESSGQKKEASG 1043

  Fly   732 SISKEPKPNDSNYRSLTPPAKITTPKMTAAQLRQRESSPKTPEK--SHDDYLTAKARIMASQPVI 794
            ..||..:..:|:    .|..|:.:......::::.......|.|  |.|..|....::|.|:|:.
Zfish  1044 KTSKSAREKESD----APREKVASTGPAIKRVKEEPPHKSEPSKTQSSDPKLMLPRKLMQSRPLK 1104

  Fly   795 NDTEMETNVGKENKAKSPLSKDRKKKKKDKDKAERKKNKKDKR---------------AKKEKGD 844
            :..|::. :..|.|:|..|.||..|:.|...| :.|.:|||..               ||::|..
Zfish  1105 HHQELKA-IKDEIKSKKDLVKDPAKQDKASGK-DGKASKKDPEKPFKMEEKIPAKVVDAKQDKKK 1167

  Fly   845 RQKKSSSVN----------RSDSDINNSSLMN----ESNYKVLSPRAQSPS-----------IEI 884
            |:...|||.          :.::|:..:|...    ||...|...:...||           |:|
Zfish  1168 RRDDKSSVKDPDGPPVKVAKMETDVVKTSPKPKPKLESERPVEKDKPAIPSLLDIKPEPVRKIKI 1232

  Fly   885 N--------------------------------------------AAQL------------SPTH 893
            |                                            :..|            ||..
Zfish  1233 NREIGKRISSTDRPVLAEDSAHGPGKGRLDKSRGKLRRKVHAPDGSGSLLVDYTSTSSTGGSPIR 1297

  Fly   894 NATENVNPKSHSILTVGAASDDNLGPRSKLSEANSVNLSKWE--------IDENILGLEDSSKKA 950
            ...|.::.|...:.|:...::|:..|.........|..||||        .|..:|....|:..:
Zfish  1298 KHEEKIDLKKTVVKTLEEYTNDSSTPAEDEIVMIQVPRSKWEKEDYESEDDDSKVLNRTSSADTS 1362

  Fly   951 AGASDDPSEITSDV-LRKAENAIFAKAINAIRPMEFQVIINS------KDNSKDRSVVRS-DKDR 1007
            ..|   ||...|.| |...|:....||.:.::..:.:...:|      ||..|||...|: :|||
Zfish  1363 VAA---PSVENSAVKLSDKESPHSDKAQSTLKEADVKPAKDSTSGDKEKDTDKDRERERTKEKDR 1424

  Fly  1008 SSS-----------------------------PRRNNSSRSVKDRLGTKIS-NDR---------- 1032
            ||:                             ..|::||:|.:||...|.. |.|
Zfish  1425 SSTTDRESTDKKKPSVPNQESAHAQEKGSDHGSERSSSSQSSRDRQADKAEPNSRKPTGRETTTG 1489

  Fly  1033 -----------------SRSRDKSKGRRR-----AARSSDDDANRGRSDRHGSRKRDNRSRDRAA 1075
                             :||:|:....||     .:|..|...:.||.:....::..:.||.:.|
Zfish  1490 PTSRKPEHRDDTKDHLGTRSKDEKNPIRRIPSSPPSRVKDLHKDSGRKNLEAPQESQSPSRTKRA 1554

  Fly  1076 PSEKRQERSYKRSSPEDDKLRRQNKEQSESKHGKHDQNNSDDSDRRAAKNTKSSDSRVVSSVTA- 1139
            |.:...|.  |||.|||      ::|...|:|.  :...|.|.:.|....|.:.:.|..:..:|
Zfish  1555 PIQNTSEP--KRSGPED------HRESQSSRHS--EVRPSKDKEHRTPHITLTPEPRTDAEKSAP 1609

  Fly  1140 -----VVAPPKPCRPDNPFRK------FV-DTSSSSSLVVKYDNTIQKEGASSDNGMEH------ 1186
                 .:...:..|..:...:      || |.|.|.|.....::..:::|...|:...|
Zfish  1610 HVDHIKIPSARLTRLSSDLARETDEAAFVPDYSESDSEASDIESKTEQKGRERDSSGSHSPSPSG 1674

  Fly  1187 -----------------RKQRD-------------KKLKKHSKYSSTDS---LKSEKRKDPKSKK 1218
                             :|:||             ||.|||.|::|.:|   ||.:|.|  ..||
Zfish  1675 SHGHSSSPSSPGSQDSKKKKRDKKEKKEKKKHKKHKKHKKHKKHTSNESESELKGQKHK--HKKK 1737

  Fly  1219 KSKILKKKKKSKK 1231
            |||..|.|.|..|
Zfish  1738 KSKKSKDKDKDDK 1750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snama	NP_611884.1	COG5222	3..315	CDD:227547	156/377 (41%)
		DWNN	3..75	CDD:285936	46/71 (65%)
		zf-CCHC_2	148..167	CDD:290419	9/18 (50%)
		RING	217..260	CDD:238093	28/42 (67%)
rbbp6	NP_001180603.1	COG5222	2..386	CDD:227547	159/391 (41%)
		DWNN	4..75	CDD:285936	46/71 (65%)
		zf-CCHC_2	153..173	CDD:290419	11/20 (55%)
		RING	257..300	CDD:238093	28/42 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592102
Domainoid	1	1.000	101	1.000	Domainoid score	I6941
eggNOG	1	0.900	-	-		E1_COG5222
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2416
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000125
OrthoInspector	1	1.000	-	-		otm24600
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15439
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1986
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.970