Protein Alignment CG10339 and NLGN2

DIOPT Version :10

• Sequence 1: NP_611881.1
• Gene: CG10339 / 37854
• FlyBaseID: FBgn0034972
• Length: 603
• Species: Drosophila melanogaster
• Sequence 2: NP_065846.1
• Gene: NLGN2 / 57555
• HGNCID: 14290
• Length: 835
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 162/567 - (28%)
• Similarity: 268/567 - (47%)
• Gaps: 84/567 - (14%)

  Fly    58 YLGIRYA----HARRFQPPDIELTPWKGIFNATVFQPDCWQN---AMPSVGKETEQILKIIQSDS 115
            :||:.||    .|||||||:...: |.|:.|||...|.|.||   |:|::      :|.:..:|:
Human    69 FLGVPYATPPLGARRFQPPEAPAS-WPGVRNATTLPPACPQNLHGALPAI------MLPVWFTDN 126

  Fly   116 --SAQDAERKYEENCLYLNVFVP--DG-----------------LPEINGYAVVVWIHSGDFSTG 159
              :|....:...|:|||||::||  ||                 :.:.....|::::|.|.:..|
Human   127 LEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEG 191

  Fly   160 SPADVEPFQLVFKQKVIVVTFSYRLNIFGFFTTDDGEAQGNYGLMDQSAALYWVKKNINFFGGDS 224
            :....:...|.....|||.|.:|||.:.||.:|.|..|:|||||:||..||.|:.:||..||||.
Human   192 TGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDP 256

  Fly   225 NRITLMGHDAGAVSVALHMTSGEWSKGGFHKAIIMSGNPLSTVKMPYEYEGSLDQVSSTFACPRR 289
            .|||:.|..|||..|.|.:.| ..|:|.|.|||..||..:|:..:.|:.......:::...|.|.
Human   257 ERITIFGSGAGASCVNLLILS-HHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDRE 320

  Fly   290 PTSMFIQCLKRIDAKRLSENLPQ-----VSWGPVVDFGLSNTSYPFIENQPEILFKKGSYHRVPV 349
            .::..::||:|..::.|.:...|     :::|||||..:       :.:.||||.::|.:....:
Human   321 DSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDV-------VPDDPEILMQQGEFLNYDM 378

  Fly   350 IIGVTDMEEVLTLFKDNLDTD--ISPSDLEGFYTDIAVTDMHKLVRN-YEWCSNYELISDAINFM 411
            :||| :..|.|...:|:.:::  :|.|..     |..|::   .|.| |.:....:::.:.|.||
Human   379 LIGV-NQGEGLKFVEDSAESEDGVSASAF-----DFTVSN---FVDNLYGYPEGKDVLRETIKFM 434

  Fly   412 YANDSDTD-AKKANKHIISAHTEKFYITPMQTFADLISN-DSQVYSYLFRMRPRSVLQDLPSWIS 474
            |.:.:|.| .:...|.:::..|:..::.|....|.|.:: .|.||.|.|....::  :..|.|..
Human   435 YTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQA--EGRPEWAD 497

  Fly   475 VPKYFDQIFVWGNPYMTNSVD-----WKSTDKKIADIIMTLWANFAKTSNP------------TK 522
            .....:..:|:|.| |..:.|     :...|..::.::||.|.|||||.:|            ||
Human   498 AAHGDELPYVFGVP-MVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTK 561

  Fly   523 SNVY--VKWNAMTPNNDSVLLIDESFNTDNLLNNQRINFWRSLYPKI 567
            .|.:  |.|:.........|.|.......:.....::.||..|.|.:
Human   562 PNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHL 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10339	NP_611881.1	COesterase	30..560	CDD:395084	158/558 (28%)
NLGN2	NP_065846.1	COesterase	42..601	CDD:395084	158/558 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..835