Protein Alignment CG10339 and NLGN4X

DIOPT Version :10

• Sequence 1: NP_611881.1
• Gene: CG10339 / 37854
• FlyBaseID: FBgn0034972
• Length: 603
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 640
• Identity: 171/640 - (26%)
• Similarity: 285/640 - (44%)
• Gaps: 129/640 - (20%)

  Fly     7 FLAYLAVFLHLVSDYCFVPVQCVDAPFIHIPG------NGVISGTYLKMFRTQNIKAYLGIRYAH 65
            :|..||:...|:......||  |:..:..|.|      |.::.          .::.|||:.||.
Human    28 WLTALAIKFTLIDSQAQYPV--VNTNYGKIRGLRTPLPNEILG----------PVEQYLGVPYAS 80

  Fly    66 ----ARRFQPPDIELTPWKGIFNATVFQPDC----------------WQNAMPSVGKETEQILKI 110
                .||||||: ..:.|.||.|.|.|...|                |..|      ..:.::..
Human    81 PPTGERRFQPPE-PPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTA------NLDTLMTY 138

  Fly   111 IQSDSSAQDAERKYEENCLYLNVFVP--DGL---------------------PEINGYAVVVWIH 152
            :|..:          |:|||||::||  ||.                     .:.:...|:|:||
Human   139 VQDQN----------EDCLYLNIYVPTEDGANTKKNADDITSNDRGEDEDIHDQNSKKPVMVYIH 193

  Fly   153 SGDFSTGSPADVEPFQLVFKQKVIVVTFSYRLNIFGFFTTDDGEAQGNYGLMDQSAALYWVKKNI 217
            .|.:..|:...::...|.....|||:|.:|||.|.||.:|.|..|:|||||:||..||.|:::|:
Human   194 GGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENV 258

  Fly   218 NFFGGDSNRITLMGHDAGAVSVALHMTSGEWSKGGFHKAIIMSGNPLSTVKMPYEYEGSLDQVSS 282
            ..||||..|:|:.|..|||..|:| :|...:|:|.|.||||.||..||:..:.|:.......::.
Human   259 GAFGGDPKRVTIFGSGAGASCVSL-LTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILAD 322

  Fly   283 TFACPRRPTSMFIQCLKRIDAKRLSEN--LP---QVSWGPVVDFGLSNTSYPFIENQPEILFKKG 342
            ...|....|:..::||:..:.|.|.:.  .|   .:::|||:|..:       |.:.|:||.::|
Human   323 KVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDV-------IPDDPQILMEQG 380

  Fly   343 SYHRVPVIIGVTDMEEVLTLFKDNL---DTDISPSDLEGFYTDIAVTDMHKLVRN-YEWCSNYEL 403
            .:....:::||...|.:  .|.|.:   :..::|:|.     |.:|::   .|.| |.:....:.
Human   381 EFLNYDIMLGVNQGEGL--KFVDGIVDNEDGVTPNDF-----DFSVSN---FVDNLYGYPEGKDT 435

  Fly   404 ISDAINFMYANDSDTD-AKKANKHIISAHTEKFYITPMQTFADLISN-DSQVYSYLFRMRPRSVL 466
            :.:.|.|||.:.:|.: .:...|.:::..|:..::.|....|||.:. .|..|.|.|....:|.:
Human   436 LRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEM 500

  Fly   467 QDLPSWISVPKYFDQI-FVWGNPYM----TNSVDWKSTDKKIADIIMTLWANFAKTSNP------ 520
            :  |||.. ..:.|:: :|:|.|.:    ..|.::...|..::.::||.|.|||||.:|
Human   501 K--PSWAD-SAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQ 562

  Fly   521 ------TKSNVY--VKWNAMTPNNDSVLLIDESFNTDNLLNNQRINFWRSLYPKI 567
                  ||.|.:  |.|:...|.:...|.|.......:.....::.||..|.|.:
Human   563 DTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHL 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10339	NP_611881.1	COesterase	30..560	CDD:395084	160/608 (26%)
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	163/615 (27%)