Protein Alignment CG10339 and NLGN1

DIOPT Version :10

• Sequence 1: NP_611881.1
• Gene: CG10339 / 37854
• FlyBaseID: FBgn0034972
• Length: 603
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 169/580 - (29%)
• Similarity: 265/580 - (45%)
• Gaps: 96/580 - (16%)

  Fly    58 YLGIRYA----HARRFQPPDIELTPWKGIFNATVFQPDCWQNAMPSVGKETEQILKIIQSD---- 114
            :||:.||    ..||||||: ..:||..|.|||.|.|.|.||.:.  |:..|.:|.:..::
Human    80 FLGVPYAAPPTGERRFQPPE-PPSPWSDIRNATQFAPVCPQNIID--GRLPEVMLPVWFTNNLDV 141

  Fly   115 --SSAQDAERKYEENCLYLNVFVP-----------DGLPEING------------YAVVVWIHSG 154
              |..||    ..|:|||||::||           |.|.:.:|            ..|:|:||.|
Human   142 VSSYVQD----QSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGG 202

  Fly   155 DFSTGSPADVEPFQLVFKQKVIVVTFSYRLNIFGFFTTDDGEAQGNYGLMDQSAALYWVKKNINF 219
            .:..|:....:...|.....|||:|.:|||.:.||.:|.|..|:|||||:|...||.|..:||.|
Human   203 SYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGF 267

  Fly   220 FGGDSNRITLMGHDAGAVSVAL----HMTSG-EWS---KGGFHKAIIMSGNPLSTVKMPYEYEGS 276
            ||||..|||:.|..||...|.|    |.:.| .||   ||.|.:||..||..||:..:.::....
Human   268 FGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKY 332

  Fly   277 LDQVSSTFACPRRPTSMFIQCLKRIDAKRLSENLPQ-----VSWGPVVDFGLSNTSYPFIENQPE 336
            ...:::...|....|...::||::...|.|.:...|     :::|||:|..:       |.:.|:
Human   333 ARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDV-------IPDDPQ 390

  Fly   337 ILFKKGSYHRVPVIIGVTDMEEVLTLFKDNL---DTDISPSDLEGFYTDIAVTDMHKLVRN-YEW 397
            ||.::|.:....:::||...|.:  .|.:|:   |..||.||.     |.||::   .|.| |.:
Human   391 ILMEQGEFLNYDIMLGVNQGEGL--KFVENIVDSDDGISASDF-----DFAVSN---FVDNLYGY 445

  Fly   398 CSNYELISDAINFMYANDSDT-DAKKANKHIISAHTEKFYITPMQTFADLISN-DSQVYSYLFRM 460
            ....:::.:.|.|||.:.:|. :.:...|.:::..|:..::.|....|||.|| .|..|.|.|..
Human   446 PEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYH 510

  Fly   461 RPRSVLQDLPSWISVPKYFDQIFVWGNPYMTNS----VDWKSTDKKIADIIMTLWANFAKTSNP- 520
            ..::  ..:|:|.......:..:|.|.|.:..:    .::...|..::.::||.|.|||||.:|
Human   511 HCQT--DQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPN 573

  Fly   521 -----------TKSNVY--VKWNAMTPNNDSVLLIDESFNTDNLLNNQRINFWRSLYPKI 567
                       ||.|.:  |.|...:..:...|.|.............::|.|..|.|.:
Human   574 QPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHL 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10339	NP_611881.1	COesterase	30..560	CDD:395084	166/571 (29%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	166/571 (29%)