DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mlp60A and CSRP3

DIOPT Version :9

Sequence 1:	NP_001137750.1	Gene:	Mlp60A / 37853	FlyBaseID:	FBgn0259209	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_003467.1	Gene:	CSRP3 / 8048	HGNCID:	2472	Length:	194	Species:	Homo sapiens

Alignment Length:	180	Identity:	89/180 - (49%)
Similarity:	111/180 - (61%)	Gaps:	14/180 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KCPACGKSVYAAEERVAGGYKFHKTCFKCSMCNKALDSTNCTEHEKELFCKNCHGRKYGPKGYGF 74
            ||.||.|:||.|||....|..||||||.|..|.||||||....||.|::||.|:||:|||||.|:
Human     9 KCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGY 73

  Fly    75 GGGAGCLSTDTGAHLNREFV-------------PPKIPPKAPDGLGCPRCGIYVYAAEQMLARGK 126
            |.||||||||||.||..:|.             |.|...|..:...|||||..|||||:::..||
Human    74 GQGAGCLSTDTGEHLGLQFQQSPKPARSVTTSNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGK 138

  Fly   127 GYHRRCFKCVQCNKTLDSTLHCDGPDKDIYCRGCYAQKFGARGYGHIGIS 176
            .:|:.||:|..|.|:|:||...| .|.::||:.|||:.||..|.|..|::
Human   139 PWHKTCFRCAICGKSLESTNVTD-KDGELYCKVCYAKNFGPTGIGFGGLT 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mlp60A	NP_001137750.1	LIM1_MLP84B_like	10..63	CDD:188788	30/52 (58%)
		LIM_CRP_like	108..161	CDD:188712	25/52 (48%)
		LIM_CRP_like	213..266	CDD:188712
		LIM	316..369	CDD:413332
		LIM_CRP_like	412..465	CDD:188712
CSRP3	NP_003467.1	Interaction with TCAP. /evidence=ECO:0000269\|PubMed:12507422	1..5
		LIM1_CRP3	9..62	CDD:188865	30/52 (58%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:P50463, ECO:0000255	64..69		3/4 (75%)
		Interaction with CLF2 and isoform 2. /evidence=ECO:0000269\|PubMed:19752190, ECO:0000269\|PubMed:24860983	94..105		0/10 (0%)
		LIM2_CRP3	120..173	CDD:188866	26/53 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142494
Domainoid	1	1.000	86	1.000	Domainoid score	I8089
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20742
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1214165at2759
OrthoFinder	1	1.000	-	-		FOG0000284
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4662
SonicParanoid	1	1.000	-	-		X318
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.880