DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mlp60A and Lima1

DIOPT Version :9

Sequence 1:	NP_001137750.1	Gene:	Mlp60A / 37853	FlyBaseID:	FBgn0259209	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001107017.1	Gene:	Lima1 / 65970	MGIID:	1920992	Length:	753	Species:	Mus musculus

Alignment Length:	236	Identity:	51/236 - (21%)
Similarity:	91/236 - (38%)	Gaps:	38/236 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 GYGHIGISSLGLMSDIRDSEWQSDMAPKASIINVEQIQAPIGEGCPRCGGVVFAAEQVL---SKG 230
            |.||  :||....|:..:|:...:: |:.|..:::...|.......:.........::.   ||.
Mouse   237 GAGH--LSSSAFNSEKNESKRNLEL-PRLSETSIKDRMAKYQAAVSKQSSPASYTNELKTSESKT 298

  Fly   231 RSWHRK---------CFKCRDCTK---TLDSIIACDGPDNEVYCKTCYGKKWGPHGYGFACGSSF 283
            ..|.:|         |...::.:|   |.:|::|...|..:..|.:....:          ....
Mouse   299 HKWEQKENVPPGPEACSVHQEGSKVSTTENSLVALSVPAEDDTCNSQVKSE----------AQQP 353

  Fly   284 LQTDGITEENLASERPFVAPDTTS--IMAPDGEGCPRCGGAVFAAELQLSKGKMYHRKCFNCARC 346
            :....::.:...|..|..:|..|:  ..||..|.|..|...|:..|..|:..:::|..||.|:.|
Mouse   354 MHPKPLSPDARTSSLPESSPSKTAKKFQAPAKESCVECQKTVYPMERLLANQQVFHISCFRCSYC 418

  Fly   347 TRPLD--SVLACDGPDDNIYCKLCYAKLFGPKG---VGYGH 382
            ...|.  :..:..|   .||||..:.:||..||   .|:||
Mouse   419 NNKLSLGTYASLHG---RIYCKPHFNQLFKSKGNYDEGFGH 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mlp60A	NP_001137750.1	LIM1_MLP84B_like	10..63	CDD:188788
		LIM_CRP_like	108..161	CDD:188712
		LIM_CRP_like	213..266	CDD:188712	11/67 (16%)
		LIM	316..369	CDD:413332	16/54 (30%)
		LIM_CRP_like	412..465	CDD:188712
Lima1	NP_001107017.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..186
		Required for interaction with NPC1L1. /evidence=ECO:0000269\|PubMed:29880681	164..166
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..326		6/49 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..379		5/47 (11%)
		LIM_Eplin_alpha_beta	388..440	CDD:188869	16/54 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..493
		Required for interaction with MYO5B. /evidence=ECO:0000269\|PubMed:29880681	491..511
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900