DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mlp60A and Mlp84B

DIOPT Version :9

Sequence 1:	NP_001137750.1	Gene:	Mlp60A / 37853	FlyBaseID:	FBgn0259209	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001303418.1	Gene:	Mlp84B / 40849	FlyBaseID:	FBgn0014863	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	335/497 - (67%)
Similarity:	386/497 - (77%)	Gaps:	17/497 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MP-FVPVETPKCPACGKSVYAAEERVAGGYKFHKTCFKCSMCNKALDSTNCTEHEKELFCKNCHG 64
            || |.|:|.||||.|||||||||||:||||.|||.||||.||||:||||||||||:||:||.|||
  Fly     1 MPSFQPIEAPKCPRCGKSVYAAEERLAGGYVFHKNCFKCGMCNKSLDSTNCTEHERELYCKTCHG 65

  Fly    65 RKYGPKGYGFGGGAGCLSTDTGAHLNRE--FVP---------PKIPPKAPDGLGCPRCGIYVYAA 118
            ||:||||||||.|||.||.|.|:...||  .||         |:...:||:|.||||||.|||||
  Fly    66 RKFGPKGYGFGTGAGTLSMDNGSQFLRENGDVPSVRNGARLEPRAIARAPEGEGCPRCGGYVYAA 130

  Fly   119 EQMLARGKGYHRRCFKCVQCNKTLDSTLHCDGPDKDIYCRGCYAQKFGARGYGHIGISSLGLMSD 183
            |||||||:.:|:.||||..|.|.|||.|.|:.|||:|||:||||:|||.:|||: |.....|.||
  Fly   131 EQMLARGRSWHKECFKCGTCKKGLDSILCCEAPDKNIYCKGCYAKKFGPKGYGY-GQGGGALQSD 194

  Fly   184 IRDSEWQSDMAPK-ASIINVEQIQAPIGEGCPRCGGVVFAAEQVLSKGRSWHRKCFKCRDCTKTL 247
            ....:   |.||: .:.|:|::|||..|||||||||||:||||.|||||.||:|||.|:||.|||
  Fly   195 CYAHD---DGAPQIRAAIDVDKIQARPGEGCPRCGGVVYAAEQKLSKGREWHKKCFNCKDCHKTL 256

  Fly   248 DSIIACDGPDNEVYCKTCYGKKWGPHGYGFACGSSFLQTDGITEENLASERPFVAPDTTSIMAPD 312
            |||.|.||||.:|||:||||||||||||||||||.||||||:||:.:::.|||..||||||.|.|
  Fly   257 DSINASDGPDRDVYCRTCYGKKWGPHGYGFACGSGFLQTDGLTEDQISANRPFYNPDTTSIKARD 321

  Fly   313 GEGCPRCGGAVFAAELQLSKGKMYHRKCFNCARCTRPLDSVLACDGPDDNIYCKLCYAKLFGPKG 377
            |||||||||||||||.||||||::|:||:|||.|.|||||||||||||.:|:|:.||.|||||||
  Fly   322 GEGCPRCGGAVFAAEQQLSKGKVWHKKCYNCADCHRPLDSVLACDGPDGDIHCRACYGKLFGPKG 386

  Fly   378 VGYGHTPTLVSTNYEYTPSCWGTIDRNGQKSENGCPRCGFMVFAAEQVKSAKNVWHKLCFYCMEC 442
            .||||.||||||:.|.|..........|.|:..|||||||.||||||:.|...:|||.||||.:|
  Fly   387 FGYGHAPTLVSTSGESTIQFPDGRPLAGPKTSGGCPRCGFAVFAAEQMISKTRIWHKRCFYCSDC 451

  Fly   443 RKYLDSTNLNDGPDGGIYCRSCYAKFYGPKGVGYGIGAGTLT 484
            ||.||||||||||||.||||:||.:.:||||||||:|||.||
  Fly   452 RKSLDSTNLNDGPDGDIYCRACYGRNFGPKGVGYGLGAGALT 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mlp60A	NP_001137750.1	LIM1_MLP84B_like	10..63	CDD:188788	43/52 (83%)
		LIM_CRP_like	108..161	CDD:188712	36/52 (69%)
		LIM_CRP_like	213..266	CDD:188712	40/52 (77%)
		LIM	316..369	CDD:413332	40/52 (77%)
		LIM_CRP_like	412..465	CDD:188712	39/52 (75%)
Mlp84B	NP_001303418.1	LIM1_MLP84B_like	11..64	CDD:188788	43/52 (83%)
		LIM_CRP_like	120..173	CDD:188712	36/52 (69%)
		LIM_CRP_like	222..275	CDD:188712	40/52 (77%)
		LIM_CRP_like	325..378	CDD:188712	40/52 (77%)
		LIM_CRP_like	421..474	CDD:188712	39/52 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446169
Domainoid	1	1.000	79	1.000	Domainoid score	I8580
eggNOG	1	0.900	-	-		E2759_KOG1700
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1214165at2759
OrthoFinder	1	1.000	-	-		FOG0000284
OrthoInspector	1	1.000	-	-		mtm966
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4662
SonicParanoid	1	1.000	-	-		X318
	9	8.780