DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mlp60A and CRIP3

DIOPT Version :9

Sequence 1:	NP_001137750.1	Gene:	Mlp60A / 37853	FlyBaseID:	FBgn0259209	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_996805.2	Gene:	CRIP3 / 401262	HGNCID:	17751	Length:	204	Species:	Homo sapiens

Alignment Length:	205	Identity:	68/205 - (33%)
Similarity:	90/205 - (43%)	Gaps:	33/205 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 CPRCGGVVFAAEQVLSKGRSWHRKCFKCRDCTKTLDSIIACDG---PDNEVYC-KTCYGKKWGPH 273
            ||||...||.||:|.|.|::|||.|.||..|    .||::..|   .:...|| |.|||..:||.
Human     5 CPRCQQPVFFAEKVSSLGKNWHRFCLKCERC----HSILSPGGHAEHNGRPYCHKPCYGALFGPR 65

  Fly   274 GYGFACGSSFLQ---------TDGITEENLASERPFV-------APDTTSIMAPDGEGCPRCGGA 322
            |.......|:|.         |..::..:.:..||..       :|........:...||.||..
Human    66 GVNIGGVGSYLYNPPTPSPGCTTPLSPSSFSPPRPRTGLPQGKKSPPHMKTFTGETSLCPGCGEP 130

  Fly   323 VFAAELQLSKGKMYHRKCFNCARCTRPLDSVLACDGPDDNI-YCKL-CYAKLFGPKGVGYGHTPT 385
            |:.||..:|.|:.:||.|..|.||.:.|.:  ......|.: ||.: ||..|||||||..|....
Human   131 VYFAEKVMSLGRNWHRPCLRCQRCHKTLTA--GSHAEHDGVPYCHVPCYGYLFGPKGVNIGDVGC 193

  Fly   386 LVSTNYEYTP 395
                 |.|.|
Human   194 -----YIYDP 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mlp60A	NP_001137750.1	LIM1_MLP84B_like	10..63	CDD:188788
		LIM_CRP_like	108..161	CDD:188712
		LIM_CRP_like	213..266	CDD:188712	24/56 (43%)
		LIM	316..369	CDD:413332	19/54 (35%)
		LIM_CRP_like	412..465	CDD:188712
CRIP3	NP_996805.2	LIM1_TLP	5..58	CDD:188860	24/56 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..112		3/27 (11%)
		LIM2_TLP	124..177	CDD:188861	19/54 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1214165at2759
OrthoFinder	1	1.000	-	-		FOG0000284
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820