DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and AREL1

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001034568.1	Gene:	AREL1 / 9870	HGNCID:	20363	Length:	823	Species:	Homo sapiens

Alignment Length:	338	Identity:	69/338 - (20%)
Similarity:	111/338 - (32%)	Gaps:	80/338 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YTISAFYMLTTMSASSNTNSLIEKEIDDEDMLSPIKSNNLVVR---VNQDTDDNLQA-------- 70
            :||...:.|.....|...|...|:. .|..:...::.|.|..|   |:.|..|..:.
Human    17 FTIKFLFELAARVVSFLQNEDRERR-GDRTIYDYVRGNYLDPRSCKVSWDWKDPYEVGHSMAFRV 80

  Fly    71 -LFDSVLNPGDAKRP-------------LQLPLRMRKL--PNSFFTPPAPSHSRANSADSTYDAG 119
             ||.....|..|.||             :::|:....|  |||.....|.:..:|...:.|...|
Human    81 HLFYKNGQPFPAHRPVGLRVHISHVELAVEIPVTQEVLQEPNSNVVKVAFTVRKAGRYEITVKLG 145

  Fly   120 SQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPS---PQHSRLAIHHSR---ARSSPASLQQNYN 178
               .:|:           ..||...|    .||.   |..:::..|.|.   ....|.:||
Human   146 ---GLNV-----------AYSPYYKI----FQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQ---- 188

  Fly   179 VRARSDAAAANNPNANPSSQQQPAGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPMSMQ- 242
            :..|.:   .:||..|..|.:.....|.   |..|.......|:.:..:...|...|...:.::
Human   189 IVPRDE---YDNPTNNSMSLRDEHNYTL---SIHELGPQEEESTGVSFEKSVTSNRQTFQVFLRL 247

  Fly   243 TVHKKQRSYDVIS----PIQLNRQLGALPPGWEQ-------AKTNDGQIY---YLNHTT--KSTQ 291
            |:|.:...:..||    ||. |.:...:....::       ..|:...||   ||.:.|  .||.
Human   248 TLHSRGCFHACISYQNQPIN-NGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAYLYNATNCSSTP 311

  Fly   292 WEDPRIQYRQQQQ 304
            |..|.:.....|:
Human   312 WHLPPMHMTSSQR 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	11/56 (20%)
		WW	266..295	CDD:395320	9/40 (23%)
		WW	335..364	CDD:395320
AREL1	NP_001034568.1	Filamin	52..158		25/123 (20%)
		Filamin	56..154	CDD:395505	21/111 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345		2/10 (20%)
		Interaction with SOCS2. /evidence=ECO:0000269\|PubMed:31578312	483..789
		HECTc	486..820	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900