DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and Hecw1

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_006516872.1	Gene:	Hecw1 / 94253	MGIID:	2444115	Length:	1605	Species:	Mus musculus

Alignment Length:	400	Identity:	68/400 - (17%)
Similarity:	112/400 - (28%)	Gaps:	192/400 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SHSRANSADSTYDAGSQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSS 169
            ||:|.:|.||.         .|........|.|.:.                     .:|...|.
Mouse   713 SHTRFSSVDSA---------KISESTVFSSQEDEEE---------------------ENSAFESV 747

  Fly   170 PASLQQNYNVRARSDAAAANNPNANPSSQQQPAGPTFPENSAQEFPSGAPASSAIDLDA------ 228
            |.|:|               :|..:|.| ...|||...|.:|   |.|..|.|...|::
Mouse   748 PDSVQ---------------SPELDPES-TNGAGPWQDELAA---PGGNAARSTEGLESPMAGPS 793

  Fly   229 ---MNTC--MSQDIPMS-MQTVHKKQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTT 287
               ...|  :....|:| :.::..:...|..|..        .|||.||....:.|:::|::|..
Mouse   794 NRREGECPILHNSQPISQLPSLRPEHHHYPTIDE--------PLPPNWEARIDSHGRVFYVDHIN 850

  Fly   288 KSTQWEDPRI---------------------QYRQQQQILMAERIKQNDVLQTTKQT-------- 323
            ::|.|:.|.:                     :|:..|:.:..||.:::...|.::|.
Mouse   851 RTTTWQRPSMAPTPDGMIRSGSVHQMEQLNRRYQNIQRTMATERAEEDSGNQNSEQIPDGGGGGG 915

  Fly   324 -------------------------------------------------------------TTST 327
                                                                         |:||
Mouse   916 GGSDSEAESSQSSLDLRREGSLSPVNSQKVTLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSST 980

  Fly   328 -------------------------------IANNLGPLPDGWEQAVTESGDLYFINHIDRTTSW 361
                                           .|:....||.|||......|..:|::|..|.|::
Mouse   981 CLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDHQGKSFFVDHNSRATTF 1045

  Fly   362 NDPR--MQSG 369
            .|||  :|:|
Mouse  1046 IDPRIPLQNG 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	35/231 (15%)
		WW	266..295	CDD:395320	10/28 (36%)
		WW	335..364	CDD:395320	10/28 (36%)
Hecw1	XP_006516872.1	HECW_N	66..185	CDD:374632
		C2_NEDL1-like	206..342	CDD:176073
		Neuromodulin	378..500	CDD:369001
		WW	829..858	CDD:366073	10/28 (36%)
		HECW1_helix	947..1013	CDD:375862	3/65 (5%)
		WW	1019..1050	CDD:197736	12/30 (40%)
		HECTc	1249..1603	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810