DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and TRIP12

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_024308991.1	Gene:	TRIP12 / 9320	HGNCID:	12306	Length:	2092	Species:	Homo sapiens

Alignment Length:	344	Identity:	63/344 - (18%)
Similarity:	124/344 - (36%)	Gaps:	90/344 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SNTNSLIEKEIDDEDMLS----------PIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQ 86
            |:::::|..:.:|.|..:          |.|.|:..|:.:...|      ::...:|..||:|..
Human    78 SSSSAVIVPQPEDPDRANTSERQKTGQVPKKDNSRGVKRSASPD------YNRTNSPSSAKKPKA 136

  Fly    87 L-----PLRMRKLPNS------------FFTPPAPSHSRANSADSTYDAGSQSSINIGNKASIVQ 134
            |     |....| |:|            ..:..:||.|:|::..|....||:|......::|.|:
Human   137 LQHTESPSETNK-PHSKSKKRHLDQEQQLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVK 200

  Fly   135 QPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQNYNVRARSDAAAANNPNANPSSQQ 199
            ...|.....|           ..|.|.....|..|..|.:...:....|.:||:.:.:::..:
Human   201 SGSGSESTGA-----------EERSAKPTKLASKSATSAKAGCSTITDSSSAASTSSSSSAVA-- 252

  Fly   200 QPAGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPMSMQTVHKKQRS-------YD---VI 254
                     :::...|.||......|.:......|...|...::..:|::|       :|   ..
Human   253 ---------SASSTVPPGARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARF 308

  Fly   255 SP-IQLNRQLGALPPGWEQAKTN-------DGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAERI 311
            || :.|.:...:| ||..:::|:       ..::..|..:||......|               .
Human   309 SPKVSLPKTKLSL-PGSSKSETSKPGPSGLQAKLASLRKSTKKRSESPP---------------A 357

  Fly   312 KQNDVLQTTKQTTTSTIAN 330
            :...:.::|:|.||.:.|:
Human   358 ELPSLRRSTRQKTTGSCAS 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	13/77 (17%)
		WW	266..295	CDD:395320	7/35 (20%)
		WW	335..364	CDD:395320
TRIP12	XP_024308991.1	SR-25	99..>233	CDD:313680	31/151 (21%)
		Arm_3	489..>714	CDD:330530
		WWE	808..874	CDD:308464
		HECTc	1690..2090	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900