DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and HERC3

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_055421.1	Gene:	HERC3 / 8916	HGNCID:	4876	Length:	1050	Species:	Homo sapiens

Alignment Length:	404	Identity:	66/404 - (16%)
Similarity:	121/404 - (29%)	Gaps:	137/404 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 HSRANSADS---TYDAGSQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPSPQHS---------- 157
            |..|.:||.   |:...|...:.:|.:......|.....:..||..|:.....||
Human   148 HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVF 212

  Fly   158 --------RLAIHHSRARSSPASL--------------QQNYNVRARSDAA-------------A 187
                    :|.:...:.|.||..:              :::..|..:|...             .
Human   213 GWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHD 277

  Fly   188 ANNPNANPSSQQQPAGPTFPENSA--QEFPSGAPASSAI---------DLDAMNTCMSQDIPMSM 241
            :.|...||....:..|....:.:.  |...:..|:|..|         .|...:|| :...|..:
Human   278 SMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTC-NVKCPSPV 341

  Fly   242 Q---TVHKKQRS-------YDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWED-- 294
            :   ..|..|.|       |.::                :|..:...|.:.|     .:::|:
Human   342 KGYWAAHSGQLSARADRFKYHIV----------------KQIFSGGDQTFVL-----CSKYENYS 385

  Fly   295 PRIQYRQQQQILMAERIKQNDVLQTTKQTTTSTIANNLGPLPDGWEQAVTESGDLYFINHIDRTT 359
            |.:.:|...|......|  ||          .|||        .|.|.::|..:...||.:.:..
Human   386 PAVDFRTMNQAHYTSLI--ND----------ETIA--------VWRQKLSEHNNANTINGVVQIL 430

  Fly   360 S----WN--------DPRMQSGLSVLDCPDNLVSSLQI---------EDNLCSNLFNDAQAIVNP 403
            |    ||        |...::...:   |...::|.::         ...:...:.|..::.:.|
Human   431 SSAACWNGSFLEKKIDEHFKTSPKI---PGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIP 492

  Fly   404 PSSHKPDDLEWYKI 417
            ..|..|.|:|..:|
Human   493 QLSSSPPDVEAMRI 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	25/165 (15%)
		WW	266..295	CDD:395320	4/30 (13%)
		WW	335..364	CDD:395320	8/40 (20%)
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	2..331	CDD:227511	28/182 (15%)
		RCC1 2	52..101
		RCC1 3	102..154		2/5 (40%)
		RCC1 4	156..207		9/50 (18%)
		RCC1 5	208..259		5/50 (10%)
		RCC1 6	261..311		5/49 (10%)
		RCC1	313..377	CDD:366085	12/80 (15%)
		RCC1 7	313..366		10/69 (14%)
		HECTc	702..1048	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900