DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and Nedd4l

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_036017204.1	Gene:	Nedd4l / 83814	MGIID:	1933754	Length:	1261	Species:	Mus musculus

Alignment Length:	341	Identity:	77/341 - (22%)
Similarity:	131/341 - (38%)	Gaps:	63/341 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SPIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQLPLRMRKLPNSFFTPPAPSHSRANSAD 113
            ||.:.:..|.|..|.|.|:....|.|::....:.|.....:.......:...||:....||.|
Mouse   571 SPQELSEEVSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDTVAEQAHLPPPSTPTRRARS-- 633

  Fly   114 STYDAGSQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQNYN 178
            ||...|.:|:.::....:....|.|..        :.:.:...:....|::|..:....:.|...
Mouse   634 STVTGGEESTPSVAYVHTTPGLPSGWE--------ERKDAKGRTYYVNHNNRTTTWTRPIMQLAE 690

  Fly   179 VRARSDAAAANNPNANPSSQ--QQPAGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPM-S 240
            ..|...|..:||....|..:  :..:.||...::..|....:|...|:.....|....|..|. |
Mouse   691 DGASGSATNSNNHLVEPQIRRPRSLSSPTVTLSAPLEGAKDSPIRRAVKDTLSNPQSPQPSPYNS 755

  Fly   241 MQTVHKKQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQQQQI 305
            .:..||..:|:              ||||||.....:|:.::::|.||:|.|||||:::    .:
Mouse   756 PKPQHKVTQSF--------------LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF----PV 802

  Fly   306 LMAERIKQNDVLQTTKQTTTSTIANNLGPLPDGWEQAVTESGDLYFINHI--------------- 355
            .|..:...|              .|:|||||.|||:.:...|..::|:|.
Mouse   803 HMRSKASLN--------------PNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRESVP 853

  Fly   356 ---DRTTSWNDPRMQS 368
               .:.|.|.|||:|:
Mouse   854 LYDSKITQWEDPRLQN 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	36/126 (29%)
		WW	266..295	CDD:395320	13/28 (46%)
		WW	335..364	CDD:395320	10/46 (22%)
Nedd4l	XP_036017204.1	PHA03378	<107..318	CDD:223065
		C2	<367..420	CDD:417471
		WW	465..491	CDD:395320
		WW	655..684	CDD:395320	4/36 (11%)
		WW	768..798	CDD:238122	14/29 (48%)
		WW	817..867	CDD:197736	13/49 (27%)
		HECTc	928..1257	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810