DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and HECTD3

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_078878.3	Gene:	HECTD3 / 79654	HGNCID:	26117	Length:	861	Species:	Homo sapiens

Alignment Length:	184	Identity:	39/184 - (21%)
Similarity:	62/184 - (33%)	Gaps:	58/184 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 NTNSLIEKEIDD---------EDML--SPIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQ 86
            |...|.:..||:         |||.  .||    :.:|:.:..||.:......|......:|.|.
Human   319 NLKKLSDVSIDETLIGDVCVLEDMTVHLPI----IEIRIVECRDDGIDVRLRGVKIKSSRQRELG 379

  Fly    87 L------PLRMRKLPNSFFTPPAPSHSRA-------NSADST---------YDAGSQSSI----- 124
            |      |..:.:.|....|.|...:.||       ...||.         :..|:.|.|
Human   380 LNADLFQPTSLVRYPRLEGTDPEVLYRRAVLLQRFIKILDSVLHHLVPAWDHTLGTFSEIKQVKQ 444

  Fly   125 -------NIGNKASIVQQPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSPA 171
                   ..|..|..::..:...| :.:|:|.|     :.|||:.|   |:.|:
Human   445 FLLLSRQRPGLVAQCLRDSESSKP-SFMPRLYI-----NRRLAMEH---RACPS 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354
		WW	266..295	CDD:395320
		WW	335..364	CDD:395320
HECTD3	NP_078878.3	APC10-HECTD3	238..371	CDD:176487	13/55 (24%)
HECTD3	NP_078878.3	HECT	579..845	CDD:366212
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900