DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and herc5.2

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	275	Identity:	57/275 - (20%)
Similarity:	96/275 - (34%)	Gaps:	90/275 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 NPNANPSSQQQPAGPTFPENSAQEFPSGA---PA---------SSAIDLDA---MNTCMSQDIPM 239
            |.:..|.|.......|..:.....:.||:   |.         |||:.|:.   ..:...||..:
Zfish   354 NESTKPKSSMNGGILTLNDRMIDRWVSGSYPWPTVKKEIKKVFSSAVCLNGSFLKPSLDEQDFDL 418

  Fly   240 SMQTVHKKQRSYDVISPIQLNRQLGALP-----PGWEQAKTNDGQIYYLNHTTKSTQWEDPRI-- 297
            ..::..|...:..|||.:....|...||     |..|::.    ::|.|.          |.:
Zfish   419 VGKSFSKLTDNEKVISEVVKVIQQTLLPSLNPKPAHEESL----RLYLLL----------PELIK 469

  Fly   298 ---QYRQQQ--QILMAERIKQNDVLQTTKQTTTSTIANNLGPLPDGWEQAVT-----ESGDLYFI 352
               ||::.:  :.|.::.::.|...:...:...|       .|||.|.:::.     ||.||  |
Zfish   470 GLEQYQRSELNKALASKILQLNSAAREMLEMFWS-------KLPDDWLKSLVKLFHKESADL--I 525

  Fly   353 NHIDRTTSWNDPRMQSGLSVLDCPDNLVSSLQIEDNLC-----------------SNLFNDAQAI 400
            :::....      |.|.|..|   .||:..||:...:|                 |:|.|..||.
Zfish   526 DYMSVCA------MDSDLKHL---QNLLRILQMAYKVCCSTHRDITISDFIIYEISDLLNALQAT 581

  Fly   401 VNPPSSHKPDDL-EW 414
            :        ||| :|
Zfish   582 I--------DDLADW 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	36/176 (20%)
		WW	266..295	CDD:395320	6/33 (18%)
		WW	335..364	CDD:395320	9/33 (27%)
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274
		RCC1	136..186	CDD:278826
		RCC1	189..238	CDD:278826
		RCC1	242..290	CDD:278826
		RCC1	296..347	CDD:278826
		HECTc	649..985	CDD:294058
		HECTc	678..984	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900