DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and ube3a

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001007319.1	Gene:	ube3a / 792398	ZFINID:	ZDB-GENE-041114-190	Length:	857	Species:	Danio rerio

Alignment Length:	263	Identity:	56/263 - (21%)
Similarity:	100/263 - (38%)	Gaps:	75/263 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 SSPASLQQNYNVRA-RSDAAAANNPN-ANPSSQQQPAGPTFPENSAQEFPSGAPASSAIDLDAMN 230
            |||...:.:.|..| ::.....||.. .:|...::.|...||||||:    ||...||.....||
Zfish    33 SSPGFQRMDNNAAAIKALELYKNNAKLCDPHPSKKGASSAFPENSAK----GAHNFSACSNGKMN 93

  Fly   231 TCMSQDIPMSMQTVH-----KKQRSYDVISPIQ-------LNRQLG-------ALPPGWEQAKTN 276
               .:|:|.:.:...     .:.:.|:::|...       |.|.:|       :|...:.:||
Zfish    94 ---HKDLPPTREDFRDLNFLTEDKVYEILSICSETEDYSPLIRVIGRVFSSAESLVQSFRKAK-- 153

  Fly   277 DGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAERIKQNDVLQTTKQTTT-STIANNLGPLPDGWE 340
                   .||             :::.:.|.|   |..|..:..|:|.: |:.|..:.|
Zfish   154 -------QHT-------------KEELKSLQA---KDEDKDEDEKETASGSSTAMEVEP------ 189

  Fly   341 QAVTESGDLYFINHIDRTTSWNDPRMQSGLSVLDCPDNLVSSLQIEDNLCSN-----LFNDAQAI 400
            :|...|||         .:|..:..:|. |..::...::.:..::.|.|.||     .|.:|...
Zfish   190 EASASSGD---------GSSHGENNVQK-LGPVEVSVDIDAVRRVYDRLLSNEKIEAAFLNALVY 244

  Fly   401 VNP 403
            ::|
Zfish   245 LSP 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	30/156 (19%)
		WW	266..295	CDD:395320	5/28 (18%)
		WW	335..364	CDD:395320	5/28 (18%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:293166	7/26 (27%)
		HECTc	505..855	CDD:238033
		HECTc	532..854	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900