DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and Wwp2

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_080106.1	Gene:	Wwp2 / 66894	MGIID:	1914144	Length:	870	Species:	Mus musculus

Alignment Length:	347	Identity:	92/347 - (26%)
Similarity:	146/347 - (42%)	Gaps:	38/347 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NSLIEKEIDDEDMLSPIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQLPLRMRKLPNSFF 99
            |:.:...:..|:..|.:....|.:.::..|.|     ..||.|........|.|.|     .|..
Mouse   116 NTQLTLNLQTENKGSVVSGGELTIFLDGPTVD-----LGSVPNGSAVTDGSQPPSR-----ESSG 170

  Fly   100 TPPAPSHSRANSADSTYDAGSQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPSPQHSRLAIHHS 164
            |..||.......:.:.:...|::..:.|..|........|||.|.....|...:...|.||....
Mouse   171 TAIAPETRHQPPSTNCFGGRSRTHRHSGGSARTATAASEQSPGARNRHRQPVKNSSSSGLANGTV 235

  Fly   165 RARSSPAS-LQQNYNVRARSDAAAANNPNANPSSQQQPAGPTFPE------NSAQEFPSGAPASS 222
            ....:||| .:::..|...|..|||.:.::||::...||..|..|      :..|:.|:.|.|.
Mouse   236 NEEPTPASEPEESSVVGVTSLPAAALSVSSNPNTTSLPAQSTPAEGEEASTSGTQQLPAAAQAP- 299

  Fly   223 AIDLDAMNTCMSQ-DIPMSMQTVHKKQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHT 286
                ||:.....| ::|        ..|.|.|....:.......||||||:.....|:.||::|.
Mouse   300 ----DALPAGWEQRELP--------NGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHN 352

  Fly   287 TKSTQWEDPRIQYRQQQQILMAERIKQNDVLQTTKQ------TTTSTIANNLGPLPDGWEQAVTE 345
            |::|.|:.|..:|.:..:...::|.:....:|...|      ::.||..:.|||||.|||:. .:
Mouse   353 TRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKR-QD 416

  Fly   346 SGDLYFINHIDRTTSWNDPRMQ 367
            :|.:|::||..|||.|.|||.|
Mouse   417 NGRVYYVNHNTRTTQWEDPRTQ 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	40/113 (35%)
		WW	266..295	CDD:395320	13/28 (46%)
		WW	335..364	CDD:395320	13/28 (46%)
Wwp2	NP_080106.1	C2_E3_ubiquitin_ligase	17..142	CDD:175988	4/25 (16%)
		PRK07003	<149..>299	CDD:235906	38/154 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..300		39/159 (25%)
		WW	302..331	CDD:366073	5/36 (14%)
		WW	332..361	CDD:366073	13/28 (46%)
		WW	407..435	CDD:366073	13/28 (46%)
		WW	447..477	CDD:238122
		HECTc	516..868	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810