DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and nedd4a

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001029358.1	Gene:	nedd4a / 619412	ZFINID:	ZDB-GENE-051005-2	Length:	910	Species:	Danio rerio

Alignment Length:	396	Identity:	86/396 - (21%)
Similarity:	149/396 - (37%)	Gaps:	92/396 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EKEIDDEDMLSPIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQ--LPLRMRKLPNS---- 97
            |..:..:|.|..:......:......::......|.:|:|...|..::  |.|:|..||.:
Zfish    96 ENRLTRDDFLGQVDVPLHQIPTEHPNNERPYTFKDFLLHPRSHKSRVKGHLRLKMTYLPKNRRCK 160

  Fly    98 ---------------FFTPP---APSH------------SRANSADSTYDAGSQSSINIGNKASI 132
                           |..|.   :|.|            .|.::...||....:|.....::.:|
Zfish   161 DDPAEQGENLDPGWEFLEPHELCSPHHPHQLPALPPGWEERQDNLGRTYYVNHESRTTQWHRPTI 225

  Fly   133 V---------QQPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQNYNVRARSDAAAA 188
            .         |:...:|..|.:.:.||.   :|..   :|.| |.||    :::.:....::...
Zfish   226 QDSQRDNEQRQETHSESQRAFLTRRQIS---EHEE---NHER-RESP----ESWEIITADESTLY 279

  Fly   189 NNPNANPSSQQQPAGPTFP---ENSAQEFPSGAPASSAIDLDAMN---TCMSQDIPMSMQTVHKK 247
            ::     .|::.|..|..|   ....:||..         |.|.|   |.::..:..:.:.|.:.
Zfish   280 SS-----LSERSPPPPHSPMEISTFCEEFNR---------LQATNDRRTSLTPQVTAAAEEVDRP 330

  Fly   248 QRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAE--- 309
            .|...::....|......||||||:.:.:.|:||::||.:::|.|..|.||..|......|.
Zfish   331 SRWRSILFTHSLLPTSAGLPPGWEEKQDSKGRIYFVNHNSRTTTWTRPLIQLIQPPSESPASPMA 395

  Fly   310 ----RIKQN--------DVLQTTKQTTTST-IANNLGPLPDGWEQAVTESGDLYFINHIDRTTSW 361
                .:.||        ||......|.|.| ...:.|.:|.|||.....||..:||:|..:||:|
Zfish   396 SGSTSLSQNAAGYALPPDVSPQHTHTHTHTHTPEHPGLMPTGWEVRSAPSGRPFFIDHNTKTTTW 460

  Fly   362 NDPRMQ 367
            :|||::
Zfish   461 DDPRLK 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	41/123 (33%)
		WW	266..295	CDD:395320	13/28 (46%)
		WW	335..364	CDD:395320	12/28 (43%)
nedd4a	NP_001029358.1	C2_NEDD4_NEDD4L	22..153	CDD:175999	10/56 (18%)
		WW	194..223	CDD:366073	4/28 (14%)
		WW	349..378	CDD:366073	13/28 (46%)
		WW	435..465	CDD:238122	14/29 (48%)
		HECTc	577..906	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910