DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and Huwe1

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_006528996.1	Gene:	Huwe1 / 59026	MGIID:	1926884	Length:	4456	Species:	Mus musculus

Alignment Length:	474	Identity:	89/474 - (18%)
Similarity:	153/474 - (32%)	Gaps:	131/474 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TMSASSNTNSLIEKEIDDEDMLSPIKSN---NLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQ-- 86
            |:.:.|:|..|.:.....:..|..:.:|   .:.|....:...|...:...:|.|..|...||
Mouse  2608 TLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLLGPSAAADILQLS 2672

  Fly    87 --LPLRMR--------------------KLPNSFFTPPAPSHSRANS------------------ 111
              |||:.|                    :|.:.||...:.:.|:|.:
Mouse  2673 SSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGTLSSIPTALTRWTEECKVL 2737

  Fly   112 -ADSTYDAGSQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQ 175
             |:|.:|..|...:.|.|....::.          .:|:.:...:..:||...::........::
Mouse  2738 DAESMHDCVSVVKVPIVNHLEFLRD----------EELEERREKRRKQLAEEETKIIDKGKEDKE 2792

  Fly   176 NYNVRARSDAAAANNPNANPSSQQQPAGPTFPENSAQEFPSGAPASSAIDLDAMNTCM-SQ---- 235
            |     |..:|.......|.|::|..:..|...:|....||...|.::...:.:.|.. ||
Mouse  2793 N-----RDQSAQCTVTKTNDSTEQNVSDGTPMPDSYPTTPSSTDAPTSESKETLGTLQPSQQQPA 2852

  Fly   236 --------DIPMSMQT-VHKKQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQ 291
                    :||..:|: ..:...|..::.||:| .:||...|..|               .::||
Mouse  2853 LPPPPSLGEIPQELQSPAEEVANSTQLLMPIEL-EELGPTRPSGE---------------AETTQ 2901

  Fly   292 WE---DPRIQYRQQQQILMAERIKQNDVL-----------QTTKQTTTSTIANNLG--PLPDGWE 340
            .|   .|.|      ..|..||.:.:|.|           ..|....:.|:...:|  |.....|
Mouse  2902 MELSPAPTI------TSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTPAAGSSE 2960

  Fly   341 QAVTES---GDLYFI-----NHIDRTTSWNDPRMQSGLSVLDCPDNLVSSLQIEDNLCSNLFNDA 397
            |....|   ||...:     ...|.:...|.|...|.      |.....|....|:..:....|:
Mouse  2961 QPTAGSSTPGDAPSVVAEVQGRPDVSRESNQPPEDSS------PPASSESSSTRDSAVAISGADS 3019

  Fly   398 QAIVNPP----SSHKPDDL 412
            :.|:..|    ||.:.|.|
Mouse  3020 RGILEEPLPSTSSEEEDPL 3038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	32/166 (19%)
		WW	266..295	CDD:395320	5/31 (16%)
		WW	335..364	CDD:395320	7/36 (19%)
Huwe1	XP_006528996.1	DUF908	92..367	CDD:399185
		DUF913	431..892	CDD:399192
		UBA_HUWE1	1395..1434	CDD:270474
		WWE	1695..1756	CDD:397111
		fibronec_FbpA	<2809..>2992	CDD:411474	41/204 (20%)
		DUF4414	3044..3071	CDD:405126
		DUF4414	3089..3120	CDD:405126
		HECTc	4101..4454	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900