DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yki and HACE1

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_065822.2	Gene:	HACE1 / 57531	HGNCID:	21033	Length:	909	Species:	Homo sapiens

Alignment Length:	275	Identity:	51/275 - (18%)
Similarity:	88/275 - (32%)	Gaps:	91/275 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 QPDGQSPIAAIPQLQIQPSPQHSRLAIHHSR---------ARSSPASLQQNYNVRARSDAAAA-- 188
            |||.        .:..:|..::..|.:|...         ::::.|.|:|...||...:....
Human   539 QPDS--------DMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQG 595

  Fly   189 ---------NNPNANPS---SQQQPAGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPMSM 241
                     :|...||.   ..|...|.||..||          :|.::.|.:|........:.:
Human   596 VVREWFDILSNEIVNPDYALFTQSADGTTFQPNS----------NSYVNPDHLNYFRFAGQILGL 650

  Fly   242 QTVHKK------QRS-YDVISPIQLNRQ-LGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQ 298
            ...|::      .|| |..|..|.:|.| :.::.|.:                .|:.||
Human   651 ALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEY----------------AKNLQW------ 693

  Fly   299 YRQQQQILMAERIKQNDVLQTTKQTTTSTIANNLG-----PL-PDGWEQAVTESGDLYFINHID- 356
                        |..||:.....:.|.|...:..|     || |.|....||::....::..:.
Human   694 ------------ILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTE 746

  Fly   357 -RTTSWNDPRMQSGL 370
             |.|....|::.:.|
Human   747 LRMTRAIQPQINAFL 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	21/119 (18%)
		WW	266..295	CDD:395320	4/28 (14%)
		WW	335..364	CDD:395320	7/31 (23%)
HACE1	NP_065822.2	Ank_2	<27..>283	CDD:330894
		ANK 1	64..93
		ANK repeat	66..95	CDD:293786
		ANK	92..217	CDD:238125
		ANK repeat	97..128	CDD:293786
		ANK 2	97..126
		ANK repeat	130..161	CDD:293786
		ANK 3	130..159
		ANK repeat	163..194	CDD:293786
		ANK 4	163..192
		ANK 5	196..226
		ANK repeat	196..221	CDD:293786
		ANK 6	228..257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..433
		HECTc	554..903	CDD:238033	47/252 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900