DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yki and HECW2

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_006712709.1	Gene:	HECW2 / 57520	HGNCID:	29853	Length:	1579	Species:	Homo sapiens

Alignment Length:	463	Identity:	89/463 - (19%)
Similarity:	140/463 - (30%)	Gaps:	164/463 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ASSNTNSL--------IEKEIDDEDMLSPIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQ 86
            |.|.|.||        :..|.:..|   |.::.::.....:...::.....||..|.....:...
Human   601 AVSETESLDQGSEPSQVSSETEPSD---PARTESVSEASTRPEGESDLECADSSCNESVTTQLSS 662

  Fly    87 LPLRMRKLPNSFFTPPAPSHSRANSADSTYDA---------GSQSSINIGNKASIVQQPDGQSPI 142
            :..|...|.::.| |..|:.|.....|....|         |||.|:.......:||.|.|:.
Human   663 VDTRCSSLESARF-PETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPSGED-- 724

  Fly   143 AAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQNYNVRARSDAAAANNPNANPSSQQQPAGPTFP 207
             ..|..:....|....|.....|..|...:            ||||.:|.....|..:..| |..
Human   725 -EGPGAESATVPDQEELGEVWQRRGSLEGA------------AAAAESPPQEEGSAGEAQG-TCE 775

  Fly   208 ENSAQEFPSGAPASSAIDLDAMNTCMSQDIPMSMQTVHKKQRSYDVISPIQLNRQLGALPPGWEQ 272
            ..:|||  .||...|    .|......:.:|...|.|.:.||..:            ||||.||.
Human   776 GATAQE--EGATGGS----QANGHQPLRSLPSVRQDVSRYQRVDE------------ALPPNWEA 822

  Fly   273 AKTNDGQIYYLNHTTKSTQWEDPRI---------------------QYRQQQQILMAERIKQND- 315
            ...:.|:|:|::|..::|.|:.|..                     :|:..::.:..||.::|.
Human   823 RIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTN 887

  Fly   316 -----------------------------------VLQTT---------------------KQTT 324
                                               :||:.                     :..|
Human   888 AIDGAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMFT 952

  Fly   325 TST-------------------------------IANNLGPLPDGWEQAVTESGDLYFINHIDRT 358
            .:|                               .||....||.|||......|..:|::|..||
Human   953 NNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFFVDHNSRT 1017

  Fly   359 TSWNDPRM 366
            |::.|||:
Human  1018 TTFIDPRL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	37/215 (17%)
		WW	266..295	CDD:395320	11/28 (39%)
		WW	335..364	CDD:395320	11/28 (39%)
HECW2	XP_006712709.1	HECW_N	45..164	CDD:318711
		C2_NEDL1-like	185..321	CDD:176073
		NESP55	<471..638	CDD:115071	8/39 (21%)
		PHA03169	591..>801	CDD:223003	47/225 (21%)
		WW	816..845	CDD:306827	11/28 (39%)
		WW	994..1023	CDD:306827	11/28 (39%)
		HECTc	1223..1577	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810