DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and PLEKHA5

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001243399.1	Gene:	PLEKHA5 / 54477	HGNCID:	30036	Length:	1282	Species:	Homo sapiens

Alignment Length:	152	Identity:	38/152 - (25%)
Similarity:	58/152 - (38%)	Gaps:	40/152 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 LNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAERIKQNDVLQTTKQT 323
            ||.:..:||..|....|..|:::::|...|||.|..|          :..|.:......|:|
Human     5 LNLEWISLPRSWTYGITRGGRVFFINEEAKSTTWLHP----------VTGEAVVTGHRRQST--- 56

  Fly   324 TTSTIANNLGPLPDGWEQAVTESGDLYFINHIDRTTSWNDPRMQSGLSVLDCPDNLVSSLQIEDN 388
                      .||.|||:|.|..|..|:|||.:|..:...|               |:....:||
Human    57 ----------DLPTGWEEAYTFEGARYYINHNERKVTCKHP---------------VTGQPSQDN 96

  Fly   389 LCSNLFNDAQAIVNPPSSHKPD 410
             |..:.|: |.:....|..|.:
Human    97 -CIFVVNE-QTVATMTSEEKKE 116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	34/142 (24%)
		WW	266..295	CDD:395320	10/28 (36%)
		WW	335..364	CDD:395320	13/28 (46%)
PLEKHA5	NP_001243399.1	WW	12..41	CDD:278809	10/28 (36%)
		WW	58..87	CDD:278809	13/28 (46%)
		PH_PEPP1_2_3	164..267	CDD:270068
		PH	170..266	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900