DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yki and NEDD4

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001271267.1	Gene:	NEDD4 / 4734	HGNCID:	7727	Length:	1319	Species:	Homo sapiens

Alignment Length:	392	Identity:	90/392 - (22%)
Similarity:	145/392 - (36%)	Gaps:	130/392 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 DDNLQALFDSVLNPG-------DAKRPLQLPLRMRKLPNSF---------------------FTP 101
            |||.:...:  |.||       ||...||.......||..:                     :..
Human   578 DDNAEQAEE--LEPGWVVLDQPDAACHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKR 640

  Fly   102 PAPSHS-----------RANSADSTYDAGSQSSINIGNKAS-----IVQQPDGQSPIAAIPQLQI 150
            |.|..:           :|..|.:|....|:.:.::.|:.|     |:::.:     |.:...|.
Human   641 PTPQDNLTDAENGNIQLQAQRAFTTRRQISEETESVDNRESSENWEIIREDE-----ATMYSNQA 700

  Fly   151 QPSPQ---------------HSRLAIHHSRARSSPASLQQNYNVRARSDAAAANNPNANPSSQQQ 200
            .|||.               ::||.|..:.|.|.||| ..|::.|..|..|.        :.::|
Human   701 FPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPAS-SSNHSSRRGSLQAY--------TFEEQ 756

  Fly   201 PAGPTFPENSAQEFPSGAP-----------ASSAIDLDAMNTCMSQDIPMSMQTVHKKQ------ 248
            |..|.....|     ||.|           .|..:|.::..|..::  |....||...|
Human   757 PTLPVLLPTS-----SGLPPGWEEKQDERGRSYYVDHNSRTTTWTK--PTVQATVETSQLTSSQS 814

  Fly   249 ------------RSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQ 301
                        ....|..|.::.:  |.||.|||.....:|:.::::|.||:|.|||||::
Human   815 SAGPQSQASTSDSGQQVTQPSEIEQ--GFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLK--- 874

  Fly   302 QQQILMAERIKQNDVLQTTKQTTTSTIANNLGPLPDGWEQAVTESGDLYFINHIDRTTSWNDPRM 366
                 :...::....|.|         :|:|||||.|||:.....|.:::|||..:.|.|.|||:
Human   875 -----IPAHLRGKTSLDT---------SNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRL 925

  Fly   367 QS 368
            ::
Human   926 EN 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	36/108 (33%)
		WW	266..295	CDD:395320	12/28 (43%)
		WW	335..364	CDD:395320	11/28 (39%)
NEDD4	NP_001271267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..229
		C2	<517..570	CDD:417471
		Mediates interaction with TNIK. /evidence=ECO:0000250	578..981		90/392 (23%)
		WW	611..643	CDD:197736	3/31 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..780		7/29 (24%)
		WW	769..798	CDD:395320	4/30 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..834		5/39 (13%)
		WW	842..871	CDD:395320	12/28 (43%)
		WW	893..925	CDD:197736	14/31 (45%)
		HECTc	986..1315	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900