DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and Nedd4

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster

Alignment Length:	362	Identity:	77/362 - (21%)
Similarity:	135/362 - (37%)	Gaps:	105/362 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TMSASSNTNSLIEKEIDDEDMLSPIKSNNLVVRV--------NQD-TDDNLQALFDSVLNPGDAK 82
            |.||..||               |..:|.::.::        :|| |.|:...:::|:.:|...:
  Fly   339 TSSAPPNT---------------PTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHR 388

  Fly    83 RP------LQLPLR-MRK---LPNSFFTPPAPSHSRANSADSTYDAGSQSSINIGNKASIVQQPD 137
            :|      ||..|| :|:   :|:...|.|....:..|.|..   ||.|...........:||
  Fly   389 QPEISATSLQNDLRPVREAPGVPDIAITNPFTRRAAGNMAGG---AGWQQERRRQQMQLHIQQ-- 448

  Fly   138 GQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQNYNVRAR-SDAAAANNPNANPSSQQQP 201
                     ..|.|...|.:|:.:.....:..|....|.:..:.| |:....:..:.|||....|
  Fly   449 ---------HQQRQQQQQQNRILLDVDHRQQEPQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAP 504

  Fly   202 AGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPMSMQTVHKKQRSYDVISPIQLNRQLGAL 266
            :    ...:::|..:..|                  ||...|..:::                .|
  Fly   505 S----TRRNSEEDNAAVP------------------PMEQNTGGEEE----------------PL 531

  Fly   267 PPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAERIKQNDVLQTTKQTTTSTIANN 331
            ||.|......:|:.::::|.::.|.|.|||                  :...:.....|..:.::
  Fly   532 PPRWSMQVAPNGRTFFIDHASRRTTWIDPR------------------NGRASPMPNQTRRVEDD 578

  Fly   332 LGPLPDGWEQAVTESGDLYFINHIDRTTSWNDPRMQS 368
            |||||:|||:.|...|.:::|:|..|||.|.|||:.:
  Fly   579 LGPLPEGWEERVHTDGRVFYIDHNTRTTQWEDPRLSN 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	31/108 (29%)
		WW	266..295	CDD:395320	8/28 (29%)
		WW	335..364	CDD:395320	13/28 (46%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809
		WW	531..560	CDD:278809	8/28 (29%)
		WW	581..613	CDD:197736	16/31 (52%)
		HECTc	650..1003	CDD:238033
		HECTc	674..1003	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810