DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and Hectd1

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_006240148.1	Gene:	Hectd1 / 362736	RGDID:	1561653	Length:	2610	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	70/340 - (20%)
Similarity:	127/340 - (37%)	Gaps:	57/340 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 APSHSRANSADSTYDAGSQSSINIGN-----------KASIVQQPDGQSPIAA------IPQLQI 150
            |.|.||..|:.|.....|.|.|::|:           :.|||...|...||..      :||.::
  Rat  1376 AGSSSRKGSSSSVCSVASSSDISLGSTKTERRSEIVMEHSIVSGADVHEPIVVLSSAENVPQTEV 1440

  Fly   151 QPSPQHSRLAI-HHSRARSSPASLQQNYNVRARSDAAAANNPNANPSSQQQPAGPTFPENSAQEF 214
            ..|...|...: ..:.:.::...|..:.:|||..:::|.:....:.||   |...:..|.:.:|.
  Rat  1441 GSSSSASTSTLTAETGSENAERKLGPDSSVRAPGESSAISMGIVSVSS---PDVSSVSELTNKEA 1502

  Fly   215 PSGAP-ASSAIDLDAMNTCMSQDIPMSMQTVHKKQRSYDVISPIQLNRQLGALPPGWEQAKTN-- 276
            .|..| :|||.:..::::.::...|||.........|.:..|.....|::..:      |:||
  Rat  1503 ASQRPLSSSASNRLSVSSLLAAGAPMSSSASVPNLSSRETSSLESFVRRVANI------ARTNAT 1561

  Fly   277 ----------DGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAERIKQNDVLQTTKQTTTSTIANN 331
                      |.....|.....||....  :...|....|..........:.|:..|::|.:|..
  Rat  1562 NNMNLSRSSSDNNTNTLGRNVMSTATSP--LMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVATA 1624

  Fly   332 LGPLPDGWEQAVTESGDLYFINHIDRTTSWNDPRMQSGLSVLDCPDNLVSSLQIEDNLCSNLFND 396
            ...|..|  |:::.:    ....:..|:|.:|...::..|:.|..|:..:|     .|.:.|.:|
  Rat  1625 TTVLSVG--QSLSNT----LTTSLTSTSSESDTGQEAEYSLYDFLDSCRAS-----TLLAELDDD 1678

  Fly   397 AQAIVNPPSSHKPDD 411
            ...    |...:.||
  Rat  1679 EDL----PEPDEEDD 1689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	27/154 (18%)
		WW	266..295	CDD:395320	7/40 (18%)
		WW	335..364	CDD:395320	5/28 (18%)
Hectd1	XP_006240148.1	Ank_2	366..457	CDD:289560
		ANK repeat	366..393	CDD:293786
		ANK	369..479	CDD:238125
		ANK repeat	396..426	CDD:293786
		ANK repeat	428..457	CDD:293786
		F5_F8_type_C	1107..1240	CDD:304887
		MIB_HERC2	1277..1335	CDD:284184
		HECTc	2131..2608	CDD:238033
		HECTc	2155..2607	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900