DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and Hace1

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_006256657.1	Gene:	Hace1 / 361866	RGDID:	1306114	Length:	916	Species:	Rattus norvegicus

Alignment Length:	334	Identity:	62/334 - (18%)
Similarity:	109/334 - (32%)	Gaps:	109/334 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 QPDGQSPIAAIPQLQIQPSPQHSRLAIHHSR---------ARSSPASLQQNYNVRARSDAAAA-- 188
            |||.        .:..:|..::..|.:|...         ::::.|.|:|...||...:....
  Rat   546 QPDS--------DMVHRPVSENDILLVHRDSIFRSSCEIVSKANCAKLKQGIAVRFHGEEGMGQG 602

  Fly   189 ---------NNPNANPS---SQQQPAGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPMSM 241
                     :|...||.   ..|...|.||..||          :|.::.|.:|........:.:
  Rat   603 VVREWFDILSNEIVNPDYALFTQSADGTTFQPNS----------NSYVNPDHLNYFRFAGQILGL 657

  Fly   242 QTVHKK------QRS-YDVISPIQLNRQ-LGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQ 298
            ...|::      .|| |..|..|.:|.| :.::.|.:                .|:.||
  Rat   658 ALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEY----------------AKNLQW------ 700

  Fly   299 YRQQQQILMAERIKQNDVLQTTKQTTTSTIANNLG-----PL-PDGWEQAVTESGDLYFINHID- 356
                        |..||:.....:.|.|...:..|     || |.|....||::....::..:.
  Rat   701 ------------ILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTE 753

  Fly   357 -RTTSWNDPRMQS---GLSVLDCPDNLVSSLQIEDN-----LCSNL----FNDAQAIVNPPSSHK 408
             |.|....|::.:   |..:...|    |.:|:.|.     |.|.:    .||........|.::
  Rat   754 LRMTRAIQPQINAFLQGFHMFIPP----SLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYE 814

  Fly   409 PDD--LEWY 415
            .:|  ::|:
  Rat   815 REDPVIQWF 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	29/163 (18%)
		WW	266..295	CDD:395320	4/28 (14%)
		WW	335..364	CDD:395320	7/31 (23%)
Hace1	XP_006256657.1	ANK repeat	66..95	CDD:293786
		ANK	66..93	CDD:197603
		Ank_2	69..194	CDD:289560
		ANK	92..217	CDD:238125
		ANK repeat	97..128	CDD:293786
		ANK repeat	130..161	CDD:293786
		Ank_2	135..222	CDD:289560
		ANK repeat	163..194	CDD:293786
		ANK repeat	196..221	CDD:293786
		Ank_4	199..249	CDD:290365
		HECTc	561..910	CDD:238033	58/311 (19%)
		HECTc	586..909	CDD:214523	54/286 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900