DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and smurf1

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001001943.1	Gene:	smurf1 / 321695	ZFINID:	ZDB-GENE-040426-2744	Length:	731	Species:	Danio rerio

Alignment Length:	355	Identity:	83/355 - (23%)
Similarity:	124/355 - (34%)	Gaps:	100/355 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 NPGDAKRPLQLPLRMRKL------PNSFFTPPAP-----------SHSRANSADSTYDA--GSQS 122
            |||..:....:.:|:..|      ...||..|.|           .|| .::..||.|.  ....
Zfish     3 NPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKVVVDGSGQCHS-TDTVKSTLDPKWNQHY 66

  Fly   123 SINIGNKASI---------VQQPDGQSPIA-------AIPQLQIQPSPQHSRLAIHHSRARSSPA 171
            .:.||...||         :.:..|...:.       ||.:|:   ...:.||.:.......|.|
Zfish    67 DLYIGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLK---DTGYQRLDLCKLNPSDSDA 128

  Fly   172 -------SLQQNYNVRARSDAAAANNPNANPSSQQQPAGPTFPENS---------AQEFPSGAPA 220
                   |||..       |...:..|..:.....:..||.|.::.         .:..|...|.
Zfish   129 VRGQIVVSLQTR-------DRIGSGGPVVDCRGLVENEGPVFEDSGPGRPLSCFMEEPMPYTDPT 186

  Fly   221 SSAIDLDAMNTCMSQDIPMSMQTVHKKQ-RSYD----VISPIQLNRQLG----ALPPGWEQAKTN 276
            .:|    ....|.:.:.|...|.:..:: |:.|    ..:|  .||..|    .||.|:||..|.
Zfish   187 GAA----GGGNCRALESPNQEQRLQAQRIRNQDSRGHTHTP--QNRPHGHQSPDLPEGYEQRTTV 245

  Fly   277 DGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAERIKQNDVLQTTKQTTTSTIANNLGPLPDGWEQ 341
            .||:|:|:..|..:.|.||||                       .:...|.....|||||.|.|.
Zfish   246 QGQVYFLHTQTGVSTWHDPRI-----------------------PRDLNSVSCEELGPLPPGREI 287

  Fly   342 AVTESGDLYFINHIDRTTSWNDPRMQSGLS 371
            ..|.||.:||::|.:|||.:.|||:...:|
Zfish   288 RSTVSGRIYFVDHNNRTTQFTDPRLHHIMS 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	39/115 (34%)
		WW	266..295	CDD:395320	12/28 (43%)
		WW	335..364	CDD:395320	13/28 (46%)
smurf1	NP_001001943.1	C2_Smurf-like	14..138	CDD:176028	24/127 (19%)
		WW	234..266	CDD:197736	14/31 (45%)
		WW	280..312	CDD:197736	16/31 (52%)
		HECTc	373..728	CDD:238033
		HECTc	397..728	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810