DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and Wwp1

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_006237992.1	Gene:	Wwp1 / 297930	RGDID:	1311734	Length:	968	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	82/320 - (25%)
Similarity:	122/320 - (38%)	Gaps:	81/320 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 PGDAKRPLQLPLRMRKLPNSFFTPPAPSHSRANS----ADSTYDAG----SQSSINIGN-KASIV 133
            |..|.||...|     .|....:.|........|    ||||...|    |:.|.:..| .::.|
  Rat   268 PQVATRPQNTP-----APKPLTSEPTSDTVNGESSSVLADSTSAMGTSLPSEDSTSTSNCTSTTV 327

  Fly   134 QQPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQNYNVRARS----DAAAANNPN-- 192
            |:|..|.|.|         |.:||. .|..:.|...|         .|||    |:.:.||..
  Rat   328 QEPPVQEPPA---------SSEHSE-CIPSASAEVGP---------EARSLIDPDSDSRNNSGFD 373

  Fly   193 --ANPSSQQQPAGPTFPENSAQEFPSG-----APASSA--IDLDAMNTCMSQDIPMSMQTVHKKQ 248
              ..|....:|..|.....:.:..|||     .|....  :|.:...|...:..|
  Rat   374 KVRQPEGCVEPLRPQSGNTNTESLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQP---------- 428

  Fly   249 RSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAERIKQ 313
                             ||||||:...:.|::||::|.|::|.|:.|.::..:..:...::|.:.
  Rat   429 -----------------LPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQL 476

  Fly   314 NDVLQTTKQ----TTTSTIANN--LGPLPDGWEQAVTESGDLYFINHIDRTTSWNDPRMQ 367
            ...:|...|    :.:...|.|  .||||.|||:.|..:..:||:||..:||.|.|||.|
  Rat   477 QGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	38/113 (34%)
		WW	266..295	CDD:395320	13/28 (46%)
		WW	335..364	CDD:395320	13/28 (46%)
Wwp1	XP_006237992.1	C2_E3_ubiquitin_ligase	67..190	CDD:175988
		PARM	243..>400	CDD:293666	38/155 (25%)
		WW	397..426	CDD:278809	6/28 (21%)
		WW	429..458	CDD:278809	13/28 (46%)
		WW	504..533	CDD:278809	13/28 (46%)
		WW	545..574	CDD:238122
		HECTc	614..966	CDD:238033
		HECTc	637..965	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810