DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and NEDD4L

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	XP_006722489.1	Gene:	NEDD4L / 23327	HGNCID:	7728	Length:	1019	Species:	Homo sapiens

Alignment Length:	341	Identity:	75/341 - (21%)
Similarity:	129/341 - (37%)	Gaps:	63/341 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SPIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQLPLRMRKLPNSFFTPPAPSHSRANSAD 113
            ||.:.:..:.|..|.|.|:....|.|::....:.|.....:...........||:....||.|
Human   329 SPQELSEELSRRLQITPDSNGEQFSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARS-- 391

  Fly   114 STYDAGSQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQNYN 178
            ||...|.:.:.::....:....|.|..        :.:.:...:....|::|..:....:.|...
Human   392 STVTGGEEPTPSVAYVHTTPGLPSGWE--------ERKDAKGRTYYVNHNNRTTTWTRPIMQLAE 448

  Fly   179 VRARSDAAAANNPNANPSSQ--QQPAGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQDIPM-S 240
            ..|...|..:||....|..:  :..:.||...::..|....:|...|:.....|....|..|. |
Human   449 DGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNS 513

  Fly   241 MQTVHKKQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQQQQI 305
            .:..||..:|:              ||||||.....:|:.::::|.||:|.|||||:::
Human   514 PKPQHKVTQSF--------------LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKF------ 558

  Fly   306 LMAERIKQNDVLQTTKQTTTSTIANNLGPLPDGWEQAVTESGDLYFINHI--------------- 355
                        ....::.||...|:|||||.|||:.:...|..::|:|.
Human   559 ------------PVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRESVP 611

  Fly   356 ---DRTTSWNDPRMQS 368
               .:.|.|.|||:|:
Human   612 SYDSKITQWEDPRLQN 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	36/126 (29%)
		WW	266..295	CDD:395320	13/28 (46%)
		WW	335..364	CDD:395320	10/46 (22%)
NEDD4L	XP_006722489.1	C2_NEDD4_NEDD4L	21..179	CDD:175999
		WW	224..250	CDD:278809
		WW	413..442	CDD:278809	4/36 (11%)
		WW	526..556	CDD:238122	14/29 (48%)
		WW	575..625	CDD:197736	13/49 (27%)
		HECTc	662..1016	CDD:238033
		HECTc	686..1015	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810