DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and yap-1

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001369894.1	Gene:	yap-1 / 181267	WormBaseID:	WBGene00008748	Length:	442	Species:	Caenorhabditis elegans

Alignment Length:	288	Identity:	67/288 - (23%)
Similarity:	104/288 - (36%)	Gaps:	80/288 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NNLVVRVNQDTDDNLQALFDS-----VLNPGDAKRPLQLPLRMRKLPNSFF----TPPAPSHSRA 109
            |...|....|.:.::.||...     ..|....|.|         ||:|::    .|.:.:||..
Worm    19 NQFSVHHYLDPNQSIHALISCSEKKYEKNQNQKKNP---------LPSSYYHQKRNPGSSAHSPY 74

  Fly   110 NSAD-STYDAGSQSSINIGNKASI----VQQP-------DGQSPIAAIPQLQIQPSPQHSRLAIH 162
            .|.| |:..|.|.:...:.|:|.|    |..|       :|||....       |.|.|..  :|
Worm    75 GSVDESSRTAVSPAMDMVSNQAPIHTRQVSAPNLHTSVNNGQSSATV-------PHPSHHN--VH 130

  Fly   163 HSRARS-SPASLQQNY-----NVRARSDAAAANNPNANPSSQQQPAGPTFPENSAQEFPSGAPAS 221
            |..::| |...:...|     :|::.|..|..:....:...|||.......|.|....|...|..
Worm   131 HQHSKSVSALPMTIGYSPVPSHVKSVSHEANYSYAGLSEIPQQQGMMQQNREKSLSLDPMRRPFM 195

  Fly   222 SAIDLDAMNTCMSQDIPMSMQTVHKKQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHT 286
            :..|:        :.:||                           |.|||....:||..|:.:|.
Worm   196 TPQDV--------EQLPM---------------------------PQGWEMCYDSDGVRYFKDHN 225

  Fly   287 TKSTQWEDPRIQYRQQQQILMAERIKQN 314
            :|:|.|:|||::.::|....:.|.|.||
Worm   226 SKTTTWDDPRLKQQEQTGFGLGENIGQN 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	19/54 (35%)
		WW	266..295	CDD:395320	11/28 (39%)
		WW	335..364	CDD:395320
yap-1	NP_001369894.1	WW	206..236	CDD:238122	13/29 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003509
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR17616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930