DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yki and Nedd4

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001344927.1	Gene:	Nedd4 / 17999	MGIID:	97297	Length:	1207	Species:	Mus musculus

Alignment Length:	344	Identity:	84/344 - (24%)
Similarity:	137/344 - (39%)	Gaps:	83/344 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 DSVLNPGDAKRPLQ--LPLRMRKLPNSFFTPPAPSHSRANSADSTYDAGSQSSINIGNKASIVQQ 135
            |.||:|...|..::  |.|:|..||.:            .|.|...|...:    :.....::.|
Mouse   507 DFVLHPRSHKSRVKGYLRLKMTYLPKN------------GSEDENADQAEE----LEPGWVVLDQ 555

  Fly   136 PDGQSPIAAIPQLQIQPSPQHSRLAI--------HHSR----ARSSP---ASLQQNYNVRARSDA 185
            ||..:.:...|:....|.....|..:        |.||    .|.||   .:.:.|.:::.::..
Mouse   556 PDAATHLPHPPEPSPLPPGWEERQDVLGRTYYVNHESRRTQWKRPSPDDDLTDEDNDDMQLQAQR 620

  Fly   186 AAANNPNAN-----PSSQQQPAG-PTFPENSAQEFPSGA---PASSAIDLDAM------------ 229
            |.......:     |.:::.|.. ....|:...|:...|   |.|..||:...
Mouse   621 AFTTRRQISEDVDGPDNRESPENWEIVREDENTEYSGQAVQSPPSGHIDVQTHLAEEFNTRLAVC 685

  Fly   230 -NTCMSQDIPM--------SMQT-VHKKQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLN 284
             |...||.:..        |:|| :.::|.:..|:.|..     ..||||||:.:.:.|:.||::
Mouse   686 GNPATSQPVTSSNHSSRGGSLQTCIFEEQPTLPVLLPTS-----SGLPPGWEEKQDDRGRSYYVD 745

  Fly   285 HTTKSTQWEDPRIQYRQQQQILMAERIKQNDVLQTTKQTTTSTIANNLGPLPDGWEQAVTESGDL 349
            |.:|:|.|..|.:|...:.:|....|.|              |.:|:|||||.|||:.....|.:
Mouse   746 HNSKTTTWSKPTMQDDPRSKIPAHLRGK--------------TDSNDLGPLPPGWEERTHTDGRV 796

  Fly   350 YFINHIDRTTSWNDPRMQS 368
            :||||..:.|.|.|||:|:
Mouse   797 FFINHNIKKTQWEDPRLQN 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	39/108 (36%)
		WW	266..295	CDD:395320	13/28 (46%)
		WW	335..364	CDD:395320	12/28 (43%)
Nedd4	NP_001344927.1	C2	<477..530	CDD:326325	8/22 (36%)
		WW	574..602	CDD:238122	5/27 (19%)
		WW	727..756	CDD:306827	13/28 (46%)
		WW	781..813	CDD:197736	15/31 (48%)
		HECTc	874..1203	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810