DRSC/TRiP Functional Genomics Resources

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Protein Alignment yki and Itch

DIOPT Version :9

Sequence 1:NP_001350857.1 Gene:yki / 37851 FlyBaseID:FBgn0034970 Length:418 Species:Drosophila melanogaster
Sequence 2:NP_001230641.1 Gene:Itch / 16396 MGIID:1202301 Length:864 Species:Mus musculus


Alignment Length:318 Identity:73/318 - (22%)
Similarity:121/318 - (38%) Gaps:104/318 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 LQIQPSPQHSRLAIHHSRARSSPASLQQNYNVRARSD-------------AAAANNPNAN----- 194
            ||::..      .:.:.....|.::.|.:...|.|.|             ||:..|..||     
Mouse   142 LQVEAE------VVTNGETSCSESTTQNDDGCRTRDDTRVSTNGSEDPEVAASGENKRANGNNSP 200

  Fly   195 --------PSSQQQPAGPTFPENSAQEFPSGAPASSAIDLDA------------MNTCMSQD--- 236
                    ||...:|:.|..|........:|:|:::: |.|.            :||..|:.   
Mouse   201 SLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSTNS-DSDGSSTGSLPPTNTNVNTSTSEGATS 264

  Fly   237 ---IPMS---------MQTVH------------------------KKQRSYDVISPIQLNRQLGA 265
               ||::         :.||.                        :|:.::|...|         
Mouse   265 GLIIPLTISGGSGPRPLNTVSQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEP--------- 320

  Fly   266 LPPGWEQAKTNDGQIYYLNHTTKSTQWEDPRIQYRQQQQILMAERIKQNDVLQTTKQ-------- 322
            ||||||:...|.|:|||::|.|::|.|:.|.::..:..:....:|.:....:|...|        
Mouse   321 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQD 385

  Fly   323 ---TTTSTIANNLGPLPDGWEQAVTESGDLYFINHIDRTTSWNDPRMQSGLSVLDCPD 377
               |:.:...:.|||||.|||:....:|.:||:||..|.|.|.|||.|..|:....|:
Mouse   386 LFATSQNKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPE 443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ykiNP_001350857.1 HUL4 <261..>404 CDD:227354 42/128 (33%)
WW 266..295 CDD:395320 15/28 (54%)
WW 335..364 CDD:395320 13/28 (46%)
ItchNP_001230641.1 C2_E3_ubiquitin_ligase 17..140 CDD:175988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..294 26/143 (18%)
WW 289..318 CDD:278809 2/28 (7%)
WW 321..350 CDD:278809 15/28 (54%)
Required for interaction with FYN. /evidence=ECO:0000250 356..432 22/75 (29%)
WW 401..430 CDD:278809 13/28 (46%)
WW 440..471 CDD:197736 1/4 (25%)
HECTc 509..862 CDD:238033
HECTc 533..861 CDD:214523
MAP kinase docking site 535..544
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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