Protein Alignment yki and Wwp1

DIOPT Version :10

• Sequence 1: NP_001350857.1
• Gene: yki / 37851
• FlyBaseID: FBgn0034970
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_796301.2
• Gene: Wwp1 / 107568
• MGIID: 1861728
• Length: 918
• Species: Mus musculus
• Alignment Length: 420
• Identity: 93/420 - (22%)
• Similarity: 147/420 - (35%)
• Gaps: 129/420 - (30%)

  Fly    35 NSLIEKEIDDEDMLSPIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQLPLRMRKLPNSFF 99
            |..:|| :.::..|| :::.|.:|:..:     |..:.|.            |.:....:.|...
Mouse   109 NRKLEK-VKEQLKLS-LENKNGIVQTGE-----LTVVLDG------------LVIEQEPVTNRSS 154

  Fly   100 TPPAPSHSRANSADSTYDAGS--------QSSINIGNKAS------------IV---QQPDGQSP 141
            :||.......::.....|..:        :.:|.|.|..|            :|   ..|...|.
Mouse   155 SPPIEIQQNGDALHENGDPATRTTPRLPVEGTIGIDNHVSTNTVVPNSCCSHVVNGENTPSSPSQ 219

  Fly   142 IAAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQNYNVRARSDAAAANN--------PNANPSSQ 198
            :||.|:....|.|           ..|:|.|    ..|...|.:..|:|        |:.:.:|.
Mouse   220 VAARPKNAPAPKP-----------VTSAPTS----DTVNGESSSVLADNTSTMGTLLPSEDTTST 269

  Fly   199 QQPAGPTFPENSAQEFPSGAPASSAI-----------------DLDAMNTCMSQDIPMSMQTVHK 246
            ......|..|...||.|:.:..|..|                 |.|:.|..:       ...|.:
Mouse   270 SNCTSTTTQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNNSV-------FDKVRQ 327

  Fly   247 KQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDP---------------R 296
            .:...:.:.|...|....|||.||||.|...|:.||::|.|::|.||.|               |
Mouse   328 PEGCVEPLRPQSGNTNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGR 392

  Fly   297 IQY------------------RQQQQILMAERIKQNDVLQTTKQ----TTTSTIANN--LGPLPD 337
            :.|                  |..:| ..::|.:....:|...|    :.:...|.|  .||||.
Mouse   393 VYYVDHNTRTTTWQRPTMESVRNFEQ-WQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPP 456

  Fly   338 GWEQAVTESGDLYFINHIDRTTSWNDPRMQ 367
            |||:.|..:..:||:||..:||.|.|||.|
Mouse   457 GWEKRVDSTDRVYFVNHNTKTTQWEDPRTQ 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	45/146 (31%)
		WW	266..295	CDD:459800	15/28 (54%)
		WW	335..364	CDD:459800	13/28 (46%)
Wwp1	NP_796301.2	C2_E3_ubiquitin_ligase	17..140	CDD:175988	8/37 (22%)
		DUF5585	<148..>381	CDD:465521	55/254 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..182		4/31 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	209..360		37/172 (22%)
		Required for interaction with and ubiquitination of AMOTL2. Required for interaction with YAP1. /evidence=ECO:0000250|UniProtKB:Q9H0M0	345..527		45/143 (31%)
		Interaction with ERBB4. /evidence=ECO:0000269|PubMed:19561640	345..525		45/143 (31%)
		WW	347..376	CDD:459800	15/28 (54%)
		HUL4	<377..918	CDD:227354	28/111 (25%)