DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yki and itcha

DIOPT Version :9

Sequence 1:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_001274024.1	Gene:	itcha / 100331274	ZFINID:	ZDB-GENE-120919-4	Length:	851	Species:	Danio rerio

Alignment Length:	380	Identity:	91/380 - (23%)
Similarity:	138/380 - (36%)	Gaps:	120/380 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EIDDEDMLSPIKSNNLVVRVNQDTDDNLQALFDSVLNPGDAKRPLQLPLRMRKLPNSFFTPPAPS 105
            ::|.|...|..:.:|.||.            .:|.|| |||.|                     |
Zfish   128 QVDAETFASEEQKHNAVVN------------GESRLN-GDAIR---------------------S 158

  Fly   106 HSRANSADSTYDAGSQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSP 170
            ...:.|:|.|.||...:...:|:.||            |.|......:|:..|      ..|..|
Zfish   159 RDSSPSSDITDDAPLPNGHAVGSSAS------------ASPSTGALRAPRPLR------PQRPPP 205

  Fly   171 ASLQQNYNVRARSDAAAANNPNANPSSQQQPAGPTFPENSAQEFPSGAPASSAIDLDAMNTCMSQ 235
            ||..::.:..|.|..:...:.::.||.:..|......|..:|...||:.::.|
Zfish   206 ASPHKHTSSTASSTGSTPTHGSSAPSPEMSPRVCVNGETESQGSSSGSGSNQA------------ 258

  Fly   236 DIPMSMQTVHKKQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKSTQWEDP----- 295
              |.:..|..:        :|...|   |.|||||||....:|::||::|..|.|.||.|
Zfish   259 --PRASPTPPR--------APAITN---GPLPPGWEQRADQNGRVYYVDHIEKRTTWERPEPLPP 310

  Fly   296 ----------RIQY-------------------------RQQQQILMA-ERIKQNDV--LQTTKQ 322
                      |:.|                         .|:.|:..| :|..|..:  ||....
Zfish   311 GWERRLDPMGRVYYVDHINRTTTWQRPTLESVRNYEEWQNQRSQLQGAMQRFNQRFIYGLQEQLA 375

  Fly   323 TTTSTIANNLGPLPDGWEQAVTESGDLYFINHIDRTTSWNDPRMQSGLSVLDCPD 377
            .|.:...:.|||||.|||:....:..:||::|..|:|.|.|||.|..|:....|:
Zfish   376 PTANKEFDPLGPLPSGWEKRTDSNRRMYFVHHPTRSTQWEDPRTQGLLNEKPLPE 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	47/160 (29%)
		WW	266..295	CDD:395320	15/28 (54%)
		WW	335..364	CDD:395320	11/28 (39%)
itcha	NP_001274024.1	C2_E3_ubiquitin_ligase	2..125	CDD:175988
		WW	276..305	CDD:278809	15/28 (54%)
		WW	308..337	CDD:278809	2/28 (7%)
		WW	387..418	CDD:197736	13/30 (43%)
		WW	427..458	CDD:197736	1/4 (25%)
		HECTc	496..849	CDD:238033
		HECTc	520..848	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910