DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ2 and CG42340

DIOPT Version :9

Sequence 1:	NP_001369164.1	Gene:	KCNQ2 / 3785	HGNCID:	6296	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001368973.1	Gene:	CG42340 / 7354472	FlyBaseID:	FBgn0259242	Length:	759	Species:	Drosophila melanogaster

Alignment Length:	391	Identity:	72/391 - (18%)
Similarity:	123/391 - (31%)	Gaps:	150/391 - (38%)

- Green bases have known domain annotations that are detailed below.

Human   241 LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRL---LAATFTLIGV 302
            ||.:.:..:::  .|.:|   .:..::|::...:|.|||:|:..|   ||.:   .|:.:.|:|:
  Fly   382 LCYVSSGAILF--HKLQN---WSVLESLYFCFTSLGTIGFGEMAP---NGAVALYTASAYILVGM 438

Human   303 SFFALPAGILGSGFALKVQEQHRQKHFEKR-----------------RNPAA----------GLI 340
            :..|:...::.:...|.::....|.|...:                 :.|:|          ||.
  Fly   439 AVVAMCFSLIQTEIVLWLRRFSVQDHVMPKAEELALVTVAVTPKPSXQRPSADPSLGVGLGVGLA 503

Human   341 QSAWRFYATNLSRTD------LHSTWQY--------------------YERTVT----------- 368
            ..|......||.:..      .|:..||                    ::|...
  Fly   504 GGALGQPQNNLGQHQTMFFGPAHTLTQYSSLPRRSHLQAANNSGGGSAFQRNTPIRRSTGIPEHH 568

Human   369 ----VPMYSSQTQTYGASRL-IPP-------------------LNQLELLRNLKSKSGLAF---- 405
                ||...|:....|...| :||                   :|...:..|:....||..
  Fly   569 LEYFVPRSISEFNLSGVGDLALPPPRRYSPNMVGGGGGMGGMGMNMGGMGMNMGMGMGLPHGLQL 633

Human   406 ----------------RKDPPPEPSPSQKVSLKDR--------------VFSSPRGVAAKGKGSP 440
                            ::.|||.|:..|.|:||.|              |.....|..|.|.|:|
  Fly   634 GPPQTLLCSAAPTVQQQQQPPPPPAQLQIVTLKPRSEKMVTFEDESKQAVGGGAVGGVAGGSGTP 698

Human   441 QAQTVRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSC 505
                    |.....:..:|.|.|   :.||      .|...||.:.....:|::...|.:||..|
  Fly   699 --------PHCPHGVPTTPRKSP---AVGD------IFMXPGAQNEAAQVDAAMRLRDSIDDALC 746

Human   506 P 506
            |
  Fly   747 P 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416	18/85 (21%)
		KCNQ_channel	448..669	CDD:397540	15/59 (25%)
		KCNQ2_u3	684..774	CDD:406935
		KCNQC3-Ank-G_bd	786..886	CDD:403240
CG42340	NP_001368973.1	Ion_trans_2	<208..264	CDD:400301
CG42340	NP_001368973.1	Ion_trans_2	380..453	CDD:400301	17/78 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010