DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ2 and Shal

DIOPT Version :9

Sequence 1:	NP_001369164.1	Gene:	KCNQ2 / 3785	HGNCID:	6296	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	89/435 - (20%)
Similarity:	162/435 - (37%)	Gaps:	117/435 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    81 LYNVLERPRGWAFIYHAYVFLLVF-----SCLVLSVFSTIKE-----YEKSSEGAL--------- 126
            ::...|.|       |.....|||     ..:.:||.:.:.|     :.....|.|
  Fly   171 MWRAFENP-------HTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIV 228

Human   127 -YILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGN 190
             :.|:...:::|..||.:|::||         ..|.||.|....:||::.::.  ..:..|...|
  Fly   229 FFCLDTACVMIFTAEYLLRLFAA---------PDRCKFVRSVMSIIDVVAIMP--YYIGLGITDN 282

Human   191 VFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFL------CLILASFL 249
            ...:.|..:||..::.|:.:..|.....::||..:.:.:.||      |||      .:|:.:.:
  Fly   283 DDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFLVFSLAMAIIIFATV 341

Human   250 VYLAEKGEN-DHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILG 313
            ::.|||..| .:|.:...|.|:.::|:||:||||..|:|..|:::....:|.||...|||..::.
  Fly   342 MFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIV 406

Human   314 SGFALKVQEQHRQKHFEKRR---------------NPAAGLI------QSAWRFYATNLSRTDLH 357
            |.|:   :..|:.:..:||:               :..|..:      ::.|....:.:...|.:
  Fly   407 SNFS---RIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWAAQESGIELDDNY 468

Human   358 STWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRK-------------DP 409
            .....:|                       |....|||.|:..:...|.:             .|
  Fly   469 RDEDIFE-----------------------LQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSP 510

Human   410 PPEPSPSQKVSLKDRVFSSPRG------VAAKGKGSPQAQTVRRS 448
            .|..||:...:....:..|..|      ..|.||..|.|...:.|
  Fly   511 SPMASPAHSTNSAAGLLQSCCGRCCSQRYQACGKYMPAASNAQNS 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416	62/258 (24%)
		KCNQ_channel	448..669	CDD:397540	1/1 (100%)
		KCNQ2_u3	684..774	CDD:406935
		KCNQC3-Ank-G_bd	786..886	CDD:403240
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727
		Ion_trans	188..415	CDD:395416	58/246 (24%)
		DUF3399	445..540	CDD:403174	15/117 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810