DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ2 and Shab

DIOPT Version :9

Sequence 1:	NP_001369164.1	Gene:	KCNQ2 / 3785	HGNCID:	6296	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	190/902 - (21%)
Similarity:	319/902 - (35%)	Gaps:	281/902 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    78 QNFLYNVLERP------RGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGA------LYILE 130
            |.:|:.:||:|      |..|.|   .:..:|.|.:.|:: :|:.:.:....|.      |.::|
  Fly   448 QKYLWELLEKPNTSFAARVIAVI---SILFIVLSTIALTL-NTLPQLQHIDNGTPQDNPQLAMVE 508

Human   131 IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLI---ASIAVLAAGSQGNVF 192
            .|.|..|.:||.:|..|:         ..:.||.:....:||::.::   .|:.:|    :.|..
  Fly   509 AVCITWFTLEYILRFSAS---------PDKWKFFKGGLNIIDLLAILPYFVSLFLL----ETNKN 560

Human   193 ATSALRSL-------RFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILA---- 246
            ||...:.:       |.::|||::::.|.....:.||..:....|||      |.|.|.||
  Fly   561 ATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKEL------GLLMLFLAMGVL 619

Human   247 --SFLVYLAEKGEND-HFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALP 308
              |.|.|.|||.|.| .|.:..:..||..||:||:||||.||.|..|:::.....:.||...|||
  Fly   620 IFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALP 684

Human   309 AGILGSGFALKVQEQHRQKHFEKRRN-----PAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVT 368
            ..|:.:.||...:.|.|::...|||.     ...|.|.|   |:..||......|
  Fly   685 IPIIVNNFAEFYKNQMRREKALKRREALDRAKREGSIVS---FHHINLKDAFAKS---------- 736

Human   369 VPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSQKVSLKDRVFSSPRGVA 433
            :.:......|...:.::.|..:.:...|:.       |:....:.:|...:|..|.  :|..|.:
  Fly   737 MDLIDVIVDTGKQTNVVHPKGKRQSTPNIG-------RQTLDVQSAPGHNLSQTDG--NSTEGES 792

Human   434 AKGKGSPQAQT------------------VRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRI 480
            ..|:......|                  .||..|::|      ..|| .:|| |...|||. .:
  Fly   793 TSGRNPATTGTGCYKNYDHVANLRNSNLHNRRGSSSEQ------DAVP-PYSF-DNPNARQT-SM 848

Human   481 KGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYD 545
            ....|.:..::|.|..:                                    :::.::.|:
  Fly   849 MAMESYRREQQALLQQQ------------------------------------QQQQQQMLQ--- 874

Human   546 VMDVIEQYS------------AGHLDMLSRIKSLQSRIDMIVGPPPPSTPRHKKYPTKGPTAPPR 598
             |..|:|.:            |.:|.|:: ..|..:.:.........|.           |||..
  Fly   875 -MQQIQQKAPNGNGGATGGGVANNLAMVA-ASSAATAVATATNASNASN-----------TAPGS 926

Human   599 ESPQYSPRVDQIVGRGPAITDKD--RTKGPAEAELPEDPSMM---GRLGKVEKQVLSMEKKLDFL 658
            |..:....     |.|..:.|.:  :.||     ||  ..||   |.:.::.:||.        |
  Fly   927 EGAEGGGD-----GDGGGVDDDNLSQAKG-----LP--IQMMITPGEVAELRRQVA--------L 971

Human   659 VNIYMQRMG----IPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCI--------------V 705
            .|:..|||.    ..|.|.|..|           .:.:|.:|..|..|.|              :
  Fly   972 ENLQNQRMDNLEQDVPVEFECCF-----------CTTKDFKEFTDAEGVISLPTSDFHKPICLEM 1025

Human   706 KIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERS- 769
            ::..:....|.....:|..||   .||.                    ||.|:.:||||....:
  Fly  1026 RLAAAGRQAGAYGLLSPLPAP---LPPL--------------------HGPLLALPPPPPLPPTS 1067

Human   770 -----LSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFS-------- 821
                 |.|....:..|..:.....|....|.:.:||...|..|..:.:| ....:|:
  Fly  1068 CAAVLLPAISQSSSTSSSYGTTTSTTIALPLDVSLRYGATICSSSNFNH-NYNNNFNTTTVGGGG 1131

Human   822 ------GFSISQSKENLDALNSCYAAV------APCAKVRPYIAEGE--SDTDSDLC 864
                  |.:.:.|..|    |:..|:|      |.| :..|::::|:  :|.:.:.|
  Fly  1132 NGTLLFGGNYNGSNNN----NADLASVDSSDTYASC-QTHPFLSQGDLTADFNDEAC 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416	71/254 (28%)
		KCNQ_channel	448..669	CDD:397540	43/241 (18%)
		KCNQ2_u3	684..774	CDD:406935	20/109 (18%)
		KCNQC3-Ank-G_bd	786..886	CDD:403240	20/101 (20%)
Shab	NP_001189037.1	BTB	309..416	CDD:197585
		BTB_2	309..408	CDD:280393
		Ion_trans	501..700	CDD:278921	64/217 (29%)
		Ion_trans_2	613..696	CDD:285168	33/82 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810