DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ2 and CG34396

DIOPT Version :9

Sequence 1:	NP_001369164.1	Gene:	KCNQ2 / 3785	HGNCID:	6296	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_611547.2	Gene:	CG34396 / 37398	FlyBaseID:	FBgn0085425	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	79/435 - (18%)
Similarity:	139/435 - (31%)	Gaps:	143/435 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   474 ARQAFRIKGAASRQNSEEASLPGEDIVDDKSCP-------CEFVTEDLTPGLKVSIRAVCVMR-- 529
            |||..|.:....|.:.|...:.|:.:..|.:.|       .:.|...:.|...:|.....::|
  Fly     7 ARQQQRHRRRLGRSHREPTPVTGDALPQDDASPDALPDPSPQMVRMQIRPPGSMSAHESKILRKR 71

Human   530 ---FLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPSTPRHKKYPTK 591
               |..|..:.:...|.      .|:.|:...:.|.:.:||             |:||||:..::
  Fly    72 DKSFASSSARSQSQPRE------AEKLSSPDANHLIKHRSL-------------SSPRHKEESSE 117

Human   592 GPTAPPRESPQYSP------------RVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRL--- 641
            ........|.|..|            |::|.:.|    .:.:|.:..||..|.|......::
  Fly   118 SELTTGSSSQQQRPIPNLGQTQDTLSRLEQNLQR----FEDERRRFEAEKRLFEREKREHKMRHR 178

Human   642 ----GKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSRE-----H 697
                .:..|::|...:||.       .|:.:|..|                   |:.|.     .
  Fly   179 QQLDNEERKRLLQSYRKLS-------DRIQLPQDE-------------------EERRRLIHSLR 217

Human   698 VDRHGCIVKIVRSSSS---TGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVR 759
            :.||.......|:.||   .....||:..|       .:|.   ::|||......|.|...:.:|
  Fly   218 LQRHEAPKTRGRNRSSGYDESSTQFSSSDA-------DATE---ETHPRPRAPKIPQGFVAAPIR 272

Human   760 IPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSIS---------IPSVDHEE 815
            ..|||....|.:.                    :|||......:.|:|         .|. ..||
  Fly   273 GAPPPPPSASTAP--------------------KPPERLSVSRNNSLSPVRPQRRSKTPE-QREE 316

Human   816 LERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTD 860
            :.|......:.:|::.:               ::|.|:|.|..::
  Fly   317 ILRKHEYLEVGESRDEV---------------IKPRISEAEQQSE 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416
		KCNQ_channel	448..669	CDD:397540	42/225 (19%)
		KCNQ2_u3	684..774	CDD:406935	21/97 (22%)
		KCNQC3-Ank-G_bd	786..886	CDD:403240	14/84 (17%)
CG34396	NP_611547.2	RILP-like	135..>217	CDD:304877	17/111 (15%)
		Ion_trans_2	<614..670	CDD:285168
		Ion_trans_2	771..847	CDD:285168
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010