DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KCNQ2 and KCNQ

DIOPT Version :9

Sequence 1:NP_001369164.1 Gene:KCNQ2 / 3785 HGNCID:6296 Length:890 Species:Homo sapiens
Sequence 2:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster


Alignment Length:1014 Identity:336/1014 - (33%)
Similarity:467/1014 - (46%) Gaps:288/1014 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    29 PGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRG-WA 92
            ||.|:|.|   :|      ..|.|:|.||.....|.    :|:..||:||:.|||.|||||| .|
  Fly    22 PGRPNSER---IL------QPRMSLLGKPLNYNRGT----RRDVRYRRLQSRLYNFLERPRGLHA 73

Human    93 FIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGW 157
            ..||..|||:||:||.|||||||||||:.:...|:.:||:.::.|.:|:..|:|::||..||:|.
  Fly    74 IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGC 138

Human   158 RGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLG 222
            .|||||.::|||:|||:.::|||.||..|:.|.||||||||.|||.|||||:|||||||||||||
  Fly   139 LGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLG 203

Human   223 SVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQT 287
            ||||||.:||:|..|||||.||.||||||:.||..||.|..:|.|||||:|||.|:||||..|.|
  Fly   204 SVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPIT 268

Human   288 WNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYAT--- 349
            |.|:|:|:...|:|:|||||||||||||||||||:|.||||..:||.|||.|||:.||.||.   
  Fly   269 WQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEH 333

Human   350 -------NLSRTDL-------------HSTWQYYERTVTVPMYSSQT-QTYGA------------ 381
                   |:.|..|             |:| .:..|..|:..:.||| ||.|.            
  Fly   334 SVSVATWNIHRVALPSPPASRASSSFKHNT-SFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGS 397

Human   382 -------SRLIPPLN----QLELLRNLKSKSGLAFRKDPPPEPS---------PSQKVSLKDRVF 426
                   :|.|..:|    .||:::|.||.:. :|.:|...|.:         .||..:|.:...
  Fly   398 SRASTRYTRTIRDINASVENLEVVQNGKSMNP-SFSEDSVAETTCLKNIKNSDASQPATLANCKL 461

Human   427 SSPRG----------------------------VAAKGKGSPQAQTV------------------ 445
            ||..|                            ..||..||.:..|:                  
  Fly   462 SSSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLS 526

Human   446 ----RRSPSADQSLE-------------------------DSPSKVPKSWSFGDRSRARQAFRIK 481
                |.:|:.|:.||                         ||||..|.|...|....|...|...
  Fly   527 LRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLET 591

Human   482 GAASRQNSEEASLPGEDIVDDKSCP-CEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYD 545
            |.:|..       |..|:.:::..| |    ..||...|.:||.:..:::.|::|||||:|:|||
  Fly   592 GFSSPN-------PIIDVANEEDEPRC----TQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYD 645

Human   546 VMDVIEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPSTPRHKKYPTKGPTAPPRESPQYSPRVDQI 610
            |.||:|||:|||:|:|.|:|.|..|:|.|:|          |..:|....       |:.::   
  Fly   646 VKDVMEQYAAGHVDLLGRVKMLHLRLDQILG----------KQGSKAKDV-------YASKI--- 690

Human   611 VGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEA 675
                                     |:..|:.|||:||..:|:|||.|:..||:       :.:.
  Fly   691 -------------------------SLASRVVKVERQVADIEEKLDILIKAYME-------DRDR 723

Human   676 YFGAKEPEPA-PPYH--SPEDSREHVDRHGCIVKIVRSS----------SSTGQKNFSAPPAA-- 725
            :...  |.|| |..|  ||.....|...:..::.:.:.:          ::|...|.|||.::  
  Fly   724 FLAL--PLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSEL 786

Human   726 ---PPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERS--------LSAYGGGNRA 779
               ...|.|.:|             |..:.     .:.|.||..:.:        |::|..|:..
  Fly   787 RSLTATQTPTTT-------------TDAIA-----TQTPMPPHVQHTATNTKSSVLNSYQLGSEK 833

Human   780 SME---FLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAA 841
            ...   |:.:.:         |......::|:.....|...:.....:|..  |..|:|:|....
  Fly   834 QQHNDVFMTELE---------NRTKKRVTLSLHRSTSEPYSKQEQRITIPD--EGADSLDSSAKP 887

Human   842 VAPCAKV-----------RPYIAEGESD------TDSDL 863
            ..|.:.:           .....|||.|      .|||:
  Fly   888 TPPDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSDI 926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNQ2NP_001369164.1 Ion_trans 92..324 CDD:395416 148/231 (64%)
KCNQ_channel 448..669 CDD:397540 69/246 (28%)
KCNQ2_u3 684..774 CDD:406935 20/115 (17%)
KCNQC3-Ank-G_bd 786..886 CDD:403240 16/95 (17%)
KCNQNP_788300.3 Ion_trans 100..305 CDD:278921 128/204 (63%)
Ion_trans_2 221..295 CDD:285168 47/73 (64%)
KCNQ_channel <619..719 CDD:281513 47/144 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 303 1.000 Domainoid score I1392
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 521 1.000 Inparanoid score I1271
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1168835at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40696
orthoMCL 1 0.900 - - OOG6_102886
Panther 1 1.100 - - O PTHR11537
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X604
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.830

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