Protein Alignment KCNQ2 and KCNQ

DIOPT Version :10

• Sequence 1: NP_001369164.1
• Gene: KCNQ2 / 3785
• HGNCID: 6296
• Length: 890
• Species: Homo sapiens
• Sequence 2: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Alignment Length: 1014
• Identity: 336/1014 - (33%)
• Similarity: 467/1014 - (46%)
• Gaps: 288/1014 - (28%)

Human    29 PGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRG-WA 92
            ||.|:|.|   :|      ..|.|:|.||.....|.    :|:..||:||:.|||.|||||| .|
  Fly    22 PGRPNSER---IL------QPRMSLLGKPLNYNRGT----RRDVRYRRLQSRLYNFLERPRGLHA 73

Human    93 FIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGW 157
            ..||..|||:||:||.|||||||||||:.:...|:.:||:.::.|.:|:..|:|::||..||:|.
  Fly    74 IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGC 138

Human   158 RGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLG 222
            .|||||.::|||:|||:.::|||.||..|:.|.||||||||.|||.|||||:|||||||||||||
  Fly   139 LGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLG 203

Human   223 SVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQT 287
            ||||||.:||:|..|||||.||.||||||:.||..||.|..:|.|||||:|||.|:||||..|.|
  Fly   204 SVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPIT 268

Human   288 WNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYAT--- 349
            |.|:|:|:...|:|:|||||||||||||||||||:|.||||..:||.|||.|||:.||.||.
  Fly   269 WQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEH 333

Human   350 -------NLSRTDL-------------HSTWQYYERTVTVPMYSSQT-QTYGA------------ 381
                   |:.|..|             |:| .:..|..|:..:.||| ||.|.
  Fly   334 SVSVATWNIHRVALPSPPASRASSSFKHNT-SFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGS 397

Human   382 -------SRLIPPLN----QLELLRNLKSKSGLAFRKDPPPEPS---------PSQKVSLKDRVF 426
                   :|.|..:|    .||:::|.||.:. :|.:|...|.:         .||..:|.:...
  Fly   398 SRASTRYTRTIRDINASVENLEVVQNGKSMNP-SFSEDSVAETTCLKNIKNSDASQPATLANCKL 461

Human   427 SSPRG----------------------------VAAKGKGSPQAQTV------------------ 445
            ||..|                            ..||..||.:..|:
  Fly   462 SSSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLS 526

Human   446 ----RRSPSADQSLE-------------------------DSPSKVPKSWSFGDRSRARQAFRIK 481
                |.:|:.|:.||                         ||||..|.|...|....|...|...
  Fly   527 LRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLET 591

Human   482 GAASRQNSEEASLPGEDIVDDKSCP-CEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYD 545
            |.:|..       |..|:.:::..| |    ..||...|.:||.:..:::.|::|||||:|:|||
  Fly   592 GFSSPN-------PIIDVANEEDEPRC----TQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYD 645

Human   546 VMDVIEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPSTPRHKKYPTKGPTAPPRESPQYSPRVDQI 610
            |.||:|||:|||:|:|.|:|.|..|:|.|:|          |..:|....       |:.::
  Fly   646 VKDVMEQYAAGHVDLLGRVKMLHLRLDQILG----------KQGSKAKDV-------YASKI--- 690

Human   611 VGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEA 675
                                     |:..|:.|||:||..:|:|||.|:..||:       :.:.
  Fly   691 -------------------------SLASRVVKVERQVADIEEKLDILIKAYME-------DRDR 723

Human   676 YFGAKEPEPA-PPYH--SPEDSREHVDRHGCIVKIVRSS----------SSTGQKNFSAPPAA-- 725
            :...  |.|| |..|  ||.....|...:..::.:.:.:          ::|...|.|||.::
  Fly   724 FLAL--PLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSEL 786

Human   726 ---PPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERS--------LSAYGGGNRA 779
               ...|.|.:|             |..:.     .:.|.||..:.:        |::|..|:..
  Fly   787 RSLTATQTPTTT-------------TDAIA-----TQTPMPPHVQHTATNTKSSVLNSYQLGSEK 833

Human   780 SME---FLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAA 841
            ...   |:.:.:         |......::|:.....|...:.....:|..  |..|:|:|....
  Fly   834 QQHNDVFMTELE---------NRTKKRVTLSLHRSTSEPYSKQEQRITIPD--EGADSLDSSAKP 887

Human   842 VAPCAKV-----------RPYIAEGESD------TDSDL 863
            ..|.:.:           .....|||.|      .|||:
  Fly   888 TPPDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSDI 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:459842	148/231 (64%)
		KCNQ_channel	448..669	CDD:460954	69/246 (28%)
		KCNQ2_u3	683..774	CDD:465213	20/116 (17%)
		KCNQC3-Ank-G_bd	786..886	CDD:463411	16/95 (17%)
KCNQ	NP_788300.3	Ion_trans	72..305	CDD:459842	148/232 (64%)
		KCNQ_channel	<619..719	CDD:460954	47/144 (33%)