DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ2 and Sh

DIOPT Version :9

Sequence 1:	NP_001369164.1	Gene:	KCNQ2 / 3785	HGNCID:	6296	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001303569.1	Gene:	Sh / 32780	FlyBaseID:	FBgn0003380	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	432	Identity:	96/432 - (22%)
Similarity:	161/432 - (37%)	Gaps:	113/432 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    94 IYHAYVFLL--VFSCL-VLSVFSTIKEYEKSSEGA-------------LYILEIVTIVVFGVEYF 142
            |...:|.||  |..|| .|..|...|.:..::.|.             .:::|.:.|:.|..|..
  Fly   231 IISVFVILLSIVIFCLETLPEFKHYKVFNTTTNGTKIEEDEVPDITDPFFLIETLCIIWFTFELT 295

Human   143 VRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAA--------------------GS 187
            ||..|.         ..:|.|.|....||||:.:|.....||.                    .|
  Fly   296 VRFLAC---------PNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKS 351

Human   188 QGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYL 252
            .....:.:.||.:|.:::.|:.::.|.....::||..:.|..:||....:..|:.::|.|..||.
  Fly   352 SNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYF 416

Human   253 AEKG-ENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGF 316
            ||.| ::..|.:..|..||.::|:||:||||..|....|:::.:...:.||...|||..::.|.|
  Fly   417 AEAGSDSSFFKSIPDGFWWAVVTMTTVGYGDMRPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNF 481

Human   317 ALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGA 381
            ..                           ||.....:.::.|  |.:....:.| |...|
  Fly   482 NY---------------------------FYHRETDQEEMQS--QNFNHVTSCP-YLPGT----- 511

Human   382 SRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSQKVSLKDRVFSSP--------RGVAAKGKG 438
                       |.:::| ||.|:        .|.|..:.|.|.|.|:|        |...|...|
  Fly   512 -----------LGQHMK-KSSLS--------ESSSDMMDLDDGVESTPGLTETHPGRSAVAPFLG 556

Human   439 SPQAQ----TVRRSPSADQSLEDSPSKVPKSWSFGDRSRARQ 476
            :.|.|    ....|.|.|:.|:....::.::..:..:.:.:|
  Fly   557 AQQQQQQPVASSLSMSIDKQLQHPLQQLTQTQLYQQQQQQQQ 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416	67/266 (25%)
		KCNQ_channel	448..669	CDD:397540	5/29 (17%)
		KCNQ2_u3	684..774	CDD:406935
		KCNQC3-Ank-G_bd	786..886	CDD:403240
Sh	NP_001303569.1	BTB_2	99..187	CDD:280393
		BTB	99..182	CDD:197585
		Ion_trans	274..488	CDD:278921	58/249 (23%)
		Ion_trans_2	403..479	CDD:285168	26/75 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810