DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ2 and Ork1

DIOPT Version :9

Sequence 1:	NP_001369164.1	Gene:	KCNQ2 / 3785	HGNCID:	6296	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster

Alignment Length:	1074	Identity:	200/1074 - (18%)
Similarity:	307/1074 - (28%)	Gaps:	451/1074 - (41%)

- Green bases have known domain annotations that are detailed below.

Human    86 ERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSS----EGALYIL--EIVTIVVFGV----- 139
            :.|..|.| |||:.|       ..:|.||: .|...|    .|.:.::  .::.|.|.|:
  Fly    85 DTPYTWTF-YHAFFF-------AFTVCSTV-GYGNISPTTFAGRMIMIAYSVIGIPVNGILFAGL 140

Human   140 -EYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAV-LAAGSQGNVFATSALRSLRF 202
             |||.|.:.|    .||.:: :.|.:.....|...:.||.::.: |..|        .||    |
  Fly   141 GEYFGRTFEA----IYRRYK-KYKMSTDMHYVPPQLGLITTVVIALIPG--------IAL----F 188

Human   203 LQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADA 267
            |                ||.|.|:.:.:.    |                          .|:.:
  Fly   189 L----------------LLPSWVFTYFEN----W--------------------------PYSIS 207

Human   268 LWWGLITLTTIGYGD-------KYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHR 325
            |::..:|.||||:||       ..|:.:.|..:.....:|....|:|...::...|..:..:..:
  Fly   208 LYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYLVMIMTFITRGLQSKK 272

Human   326 QKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQ------YYERTVTVPMYSSQTQTYGASRL 384
            ..:.|::              .::||..|. :..|.      .|.|.:...:|..:.:.......
  Fly   273 LAYLEQQ--------------LSSNLKATQ-NRIWSGVTKDVGYLRRMLNELYILKVKFCRKGNR 322

Human   385 IPPLNQLELLRNLKSKSGLA--------------FRKDPPPEPSPSQKVSLKDRVFSSPRGVAA- 434
            ..|.|:.:..:..||...:|              :|.:|.|.||..:..|:...:.::.|....
  Fly   323 KKPKNKAKTEQKKKSSRYIAYTLPRSNSCPDLSMYRVEPAPIPSRKRAFSVCADMVAAQREAGMV 387

Human   435 ------------KGKGSPQAQTVRRS----------------PSADQSLED----------SPSK 461
                        :.|....|:..|::                |.|:|  ||          |.|:
  Fly   388 HANSDTELSKLDREKTFETAEAYRQTTDLLAKVVNALATVKPPPAEQ--EDAALYGGYHGFSDSQ 450

Human   462 VPKS-WSF-------------------------------------------GDRSRARQAF---- 478
            :..| |||                                           ||..:.::||
  Fly   451 ILASEWSFSTVNEFTSPRRPRARACSDFNLEAPRWQSERPLRSSHNEWTWSGDNQQIQEAFNQRY 515

Human   479 ----RIKGAAS------RQNSEEASL----PGEDIVDDKSCPCEFVTEDLTPGLKVSIRAVCVMR 529
                |..|||:      ..::.|..|    ||...|...|.|         .||:        ..
  Fly   516 KGQQRANGAANSTMVHLEPDALEEQLKKQSPGAGRVKKFSMP---------DGLR--------RL 563

Human   530 FLVSKRKFKESL-RPYDVMD----VIEQYSAGHLDMLSR---IKSLQSRIDMIVGPPPP------ 580
            |...|::..:.| |...|:.    ||.|.:...||..|.   ..|.||.:....|||||
  Fly   564 FPFQKKRPSQDLERKLSVVSVPEGVISQQARSPLDYYSNTVTAASSQSYLRNGRGPPPPFESNGS 628

Human   581 ------------------STP---------------------------------RHKKYP----- 589
                              :||                                 |...||
  Fly   629 LASGGGGLTNMGFQMEDGATPPSALGGGAYQRKAAAGKRRRESIYTQNQAPSARRGSMYPPTAHA 693

Human   590 ------------TKGP-------------------------TAPPRESPQYS--PRVDQIVGRGP 615
                        |.|.                         |:.||.|..:|  ...|..|....
  Fly   694 LAQMQMRRGSLATSGSGSAAMAAVAARRGSLFPATASASSLTSAPRRSSIFSVTSEKDMNVLEQT 758

Human   616 AITD-------------------------------------KDRTKGPAEAELPEDPSMMGRLGK 643
            .|.|                                     |.|..|.|..|.|:.|.::.....
  Fly   759 TIADLIRALEVVHTHAVLDEQQQAAAAGGAAGGGGISRGSRKQRKMGNAGLEPPQLPPILSLFAG 823

Human   644 VEKQVLSMEKKLDFLVNIYMQR---MGIPPTETEAYFGAKEP--EPAPPYHSPEDSREHVDRHGC 703
            .:.:.|....    ...:|.:|   :||.||...|...|...  ||.|.|.....::..:.....
  Fly   824 DQTRTLQAAA----ANRLYARRSTIVGISPTGGAATAPAARSLLEPPPSYTERAANQSQITAGPS 884

Human   704 IVKIVRSSSSTGQKNFSAPPAA---PPVQCPP----------------STSWQPQSHPRQGHGTS 749
            ....|:|..   ::.||..|.|   ||.|.||                ..|.:|....|:...||
  Fly   885 NAPTVQSKF---RRRFSVRPTALQIPPGQAPPPGASLMEQSSQTALQRRLSLRPSPLARELSPTS 946

Human   750 PVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTP-GCRPPEGNLRDSDTSISIPSVDH 813
            |.|..||.:   |..|.:.|     ||..|.    |....| |.||.             .|..|
  Fly   947 PPGGSGSAL---PAGAIDES-----GGTSAQ----RLLPLPAGTRPS-------------TSSTH 986

Human   814 EELERSFSGFSISQSKENLDALNSCYAAVAPCAK 847
            ..|.|... .|.:|.|.::.:..:..::.||..|
  Fly   987 SPLSRIVQ-ISQAQRKSSMPSAAATGSSGAPAEK 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416	51/251 (20%)
		KCNQ_channel	448..669	CDD:397540	74/457 (16%)
		KCNQ2_u3	684..774	CDD:406935	26/108 (24%)
		KCNQC3-Ank-G_bd	786..886	CDD:403240	14/63 (22%)
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	16/62 (26%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	24/133 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010