Protein Alignment KCNQ2 and Kcnq2

DIOPT Version :10

• Sequence 1: NP_001369164.1
• Gene: KCNQ2 / 3785
• HGNCID: 6296
• Length: 890
• Species: Homo sapiens
• Sequence 2: XP_017171224.1
• Gene: Kcnq2 / 16536
• MGIID: 1309503
• Length: 937
• Species: Mus musculus
• Alignment Length: 940
• Identity: 850/940 - (90%)
• Similarity: 863/940 - (91%)
• Gaps: 53/940 - (5%)

Human     1 MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAG 65
            |||||||||||||.||||||||||||||||||||||||||||||||||||||:|||||.||||||
Mouse     1 MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAG 65

Human    66 KPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 KPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILE 130

Human   131 IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATS 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 IVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATS 195

Human   196 ALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDH 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 ALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDH 260

Human   261 FDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHR 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 FDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHR 325

Human   326 QKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQ 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 QKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQ 390

Human   391 LELLRNLKSKSGLAFRKDPPPEPSP------------------SQKVSLKDRVFSSPRGVAAKGK 437
            |||||||||||||.|||:|.|||||                  ||||||||||||||||:|||||
Mouse   391 LELLRNLKSKSGLTFRKEPQPEPSPSKGRPCRGCLCGCCPGHSSQKVSLKDRVFSSPRGMAAKGK 455

Human   438 GSPQAQTVRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDD 502
            ||||||||||||||||||:|||||||||||||||||.||||||||||||||||||||||||||:|
Mouse   456 GSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRTRQAFRIKGAASRQNSEEASLPGEDIVED 520

Human   503 -KSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKS 566
             |||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 NKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKS 585

Human   567 LQS-------------------------------RIDMIVGPPPPSTPRHKKYPTKGPTAPPRES 600
            |||                               |||||||||||||||||||||||||||.|||
Mouse   586 LQSRQEPLPVQSGHEQGPPGQNQAWHKGHQGLGDRIDMIVGPPPPSTPRHKKYPTKGPTAPSRES 650

Human   601 PQYSPRVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQR 665
            |||||||||||||||.||||||||||||.||||||||||||||||||||||||||||||:||.||
Mouse   651 PQYSPRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQR 715

Human   666 MGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQC 730
            |||||.||||||||||||||||||||||||:|.|:||||:|||||:|||||:|::||||.||.||
Mouse   716 MGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRNYAAPPAIPPAQC 780

Human   731 PPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPP 795
            ||||||| |||.|  |||||||||||||||||||||||||||||||||||.||||.|.||.|||.
Mouse   781 PPSTSWQ-QSHQR--HGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASTEFLRLEGTPACRPS 842

Human   796 EGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTD 860
            |..|||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
Mouse   843 EAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALGSCYAAVAPCAKVRPYIAEGESDTD 907

Human   861 SDLCTPCGPPPRSATGEGPFGDVGWAGPRK 890
            |||||||||||||||||||||||.||||||
Mouse   908 SDLCTPCGPPPRSATGEGPFGDVAWAGPRK 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:459842	231/231 (100%)
		KCNQ_channel	448..669	CDD:460954	211/252 (84%)
		KCNQ2_u3	683..774	CDD:465213	76/90 (84%)
		KCNQC3-Ank-G_bd	786..886	CDD:463411	91/99 (92%)
Kcnq2	XP_017171224.1	Ion_trans	92..324	CDD:459842	231/231 (100%)
		KCNQ_channel	466..719	CDD:460954	211/252 (84%)
		KCNQ2_u3	733..821	CDD:465213	76/90 (84%)
		KCNQC3-Ank-G_bd	833..933	CDD:463411	91/99 (92%)