DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF5 and EIF5A

DIOPT Version :9

Sequence 1:	NP_611878.1	Gene:	eEF5 / 37846	FlyBaseID:	FBgn0285952	Length:	159	Species:	Drosophila melanogaster
Sequence 2:	XP_024306398.1	Gene:	EIF5A / 1984	HGNCID:	3300	Length:	216	Species:	Homo sapiens

Alignment Length:	184	Identity:	105/184 - (57%)
Similarity:	129/184 - (70%)	Gaps:	34/184 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAELDDQFETTDSGASTTYPMQCSALRKNGFVMLKSRPCKIVEMSTSKTGKHGHAKVHMVGIDIF 65
            ||: |..|||.|:|||.|:|||||||||||||:||.||||||||||||||||||||||:||||||
Human    31 MAD-DLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIF 94

  Fly    66 SNKKYEDICPSTHNMDVPNVKREDLQLIAISDDSFLTLMTESGDLREDLKVPEGELGEQLRLDFD 130
            :.|||||||||||||||||:||.|.|||.| .|.:|:|:.:||::||||::|||:||:::...:|
Human    95 TGKKYEDICPSTHNMDVPNIKRNDFQLIGI-QDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYD 158

  Fly   131 SGKDL------------LC--------------------TVLKACGEECVIAIK 152
            .|:::            ||                    |||.|..||..:|||
Human   159 CGEEILVWCLPPCFCAQLCSVRFFLSSDISWLSLLLLQITVLSAMTEEAAVAIK 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF5	NP_611878.1	PLN03107	1..152	CDD:215580	103/182 (57%)
eEF5	NP_611878.1	eIF-5a	84..152	CDD:279611	33/99 (33%)
EIF5A	XP_024306398.1	PRK03999	31..212	CDD:333252	103/182 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149574
Domainoid	1	1.000	148	1.000	Domainoid score	I4470
eggNOG	1	0.900	-	-		E1_COG0231
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3587
Isobase	1	0.950	-	0	Normalized mean entropy	S164
OMA	1	1.010	-	-		QHG53968
OrthoDB	1	1.010	-	-		D1370513at2759
OrthoFinder	1	1.000	-	-		FOG0001335
OrthoInspector	1	1.000	-	-		otm41920
orthoMCL	1	0.900	-	-		OOG6_100628
Panther	1	1.100	-	-	LDO	PTHR11673
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2157
SonicParanoid	1	1.000	-	-		X827
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750