DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eEF5 and EIF5AL1

DIOPT Version :9

Sequence 1:	NP_611878.1	Gene:	eEF5 / 37846	FlyBaseID:	FBgn0285952	Length:	159	Species:	Drosophila melanogaster
Sequence 2:	NP_001093162.1	Gene:	EIF5AL1 / 143244	HGNCID:	17419	Length:	154	Species:	Homo sapiens

Alignment Length:	152	Identity:	101/152 - (66%)
Similarity:	125/152 - (82%)	Gaps:	2/152 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAELDDQFETTDSGASTTYPMQCSALRKNGFVMLKSRPCKIVEMSTSKTGKHGHAKVHMVGIDIF 65
            ||: |..|||.|:|||.|:|||||||||||||:||..||||||||.||||||||||||:||||||
Human     1 MAD-DLDFETGDAGASATFPMQCSALRKNGFVVLKGWPCKIVEMSASKTGKHGHAKVHLVGIDIF 64

  Fly    66 SNKKYEDICPSTHNMDVPNVKREDLQLIAISDDSFLTLMTESGDLREDLKVPEGELGEQLRLDFD 130
            :.|||||||||||||||||:||.|.|||.| .|.:|:|:.:||::.|||::|||:||:::...:|
Human    65 TGKKYEDICPSTHNMDVPNIKRNDFQLIGI-QDGYLSLLQDSGEVPEDLRLPEGDLGKEIEQKYD 128

  Fly   131 SGKDLLCTVLKACGEECVIAIK 152
            .|:::|.|||.|..||..:|||
Human   129 CGEEILITVLSAMTEEAAVAIK 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eEF5	NP_611878.1	PLN03107	1..152	CDD:215580	99/150 (66%)
eEF5	NP_611878.1	eIF-5a	84..152	CDD:279611	31/67 (46%)
EIF5AL1	NP_001093162.1	PLN03107	1..150	CDD:215580	99/150 (66%)
EIF5AL1	NP_001093162.1	S1_eIF5A	84..152	CDD:239914	32/68 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149575
Domainoid	1	1.000	148	1.000	Domainoid score	I4470
eggNOG	1	0.900	-	-		E1_COG0231
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100947
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3587
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53968
OrthoDB	1	1.010	-	-		D1370513at2759
OrthoFinder	1	1.000	-	-		FOG0001335
OrthoInspector	1	1.000	-	-		otm41920
orthoMCL	1	0.900	-	-		OOG6_100628
Panther	1	1.100	-	-	O	PTHR11673
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X827
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770