DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk29 and Asic5

DIOPT Version :10

Sequence 1:NP_001097442.2 Gene:ppk29 / 37844 FlyBaseID:FBgn0034965 Length:425 Species:Drosophila melanogaster
Sequence 2:NP_067345.1 Gene:Asic5 / 58170 MGIID:1929259 Length:495 Species:Mus musculus


Alignment Length:480 Identity:97/480 - (20%)
Similarity:173/480 - (36%) Gaps:130/480 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 NFRGFIRSFVENKG----LLWIFV----IGISGWSTVSILVLLKTRYETDSTTIGVSTAYSRWIN 64
            :|.| |.:..:|:.    ::|:.|    :.:..|...|.||    .|.|..||..:...|...|.
Mouse    46 SFHG-IHNIAQNQNKVRKVIWLAVVLGSVSLLVWQIYSRLV----NYFTWPTTTSIEVQYVEKIE 105

  Fly    65 TFPSIGIC---LTKSRAFNEFKAMMREYFQEDFAFSFTRMIYEYAFLNPNNIFTKEPTKNTSYPY 126
             ||::.:|   ..::.|.:.|..:.       |.:.....:.....::.||..:.|.....:...
Mouse   106 -FPAVTLCNLNRFQTEAVSRFGIIF-------FLWDIVSKVLRLQEISANNTGSPETLDFVTNHQ 162

  Fly   127 NFNILDIRRKMFPTNCTECFKE--IYFRGELVTDCE--------EIFKFHVTEMGYCFLAN---N 178
            ||:|            ||..|.  .|...:.:..||        :.||...||.|.||..|   |
Mouse   163 NFSI------------TEFVKNNGFYLNNDTLVHCEFFGKTCSPKDFKHVFTEYGNCFTFNYGEN 215

  Fly   179 LLDYDSIEEMPLRYSSLDNNRSLRL----------------YMRSSVMYKYEMYVNSPEDLPFFN 227
            :.:.:.:..         :.|.|:|                :..:.|::    .::||:..|.|:
Mouse   216 IQNKNKVSV---------SGRGLKLLLDVHQEEFTDNPVPGFADAGVIF----VIHSPKKEPQFD 267

  Fly   228 SLTYTISTDPTTYAFNVEEIHNHEGVIDEPISQRKCKFP-----SESSIEGF-PYSFSACMSIIR 286
            .|..:            ..:..|..|....:.....::|     ....:..| .||...|:...:
Mouse   268 GLGLS------------SPVGMHARVTIRQLKTVHQEYPWGECNPNIKLRNFITYSTYGCLKECK 320

  Fly   287 SEFEMKTCDCSLF------NPKDRNESLYCGLQHADCLIKEGFATRVKEYVGS-STVCLPSCVEQ 344
            :....:.|.|..|      ...|..|...|.....|.:.::|..|     :|: ::.|..||.|.
Mouse   321 ARHIQRLCGCLPFLLPGNGVECDLLEYYNCVSPILDHIERKGLCT-----MGTHNSSCPVSCEET 380

  Fly   345 Q----ISLVGVITENGTLY----NNNTQ------ITEIQIASPPTVRYERKVTQTKL-----DLI 390
            :    :|.....::..|.:    .|.:|      :..|:| :...:.|  |:||.:.     :|:
Mouse   381 EYPATVSYSTFPSQRATRFLAKKLNQSQEYIRENLVNIEI-NYSDLNY--KITQQQKAVSVPELL 442

  Fly   391 VGIGSVAGLFFGASLLNLLEIISYF 415
            ..:|...|||.||||:.::|||.||
Mouse   443 ADVGGQLGLFCGASLITIIEIIEYF 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk29NP_001097442.2 ASC 8..415 CDD:459966 95/478 (20%)
Asic5NP_067345.1 Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5 1..30
ASC 41..466 CDD:459966 95/477 (20%)
GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348 454..456 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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