DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk29 and ASIC4

DIOPT Version :9

Sequence 1:	NP_001097442.2	Gene:	ppk29 / 37844	FlyBaseID:	FBgn0034965	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_061144.4	Gene:	ASIC4 / 55515	HGNCID:	21263	Length:	539	Species:	Homo sapiens

Alignment Length:	444	Identity:	87/444 - (19%)
Similarity:	150/444 - (33%)	Gaps:	146/444 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 YETDSTTIGVSTAYSRWINTFPSIGICLTKSRAFNEFKAMMREYFQEDFAFSFTRMIYEYAFLNP 110
            |.|....:.:..|....:..||::.:|     ..|.|:                     ::.|:.
Human    92 YLTRPHLVAMDPAAPAPVAGFPAVTLC-----NINRFR---------------------HSALSD 130

  Fly   111 NNIF-----TKEPTKNTS--------YPYNFNILDIRRKMFPTNCTECFKEIYFRGELVTDCE-E 161
            .:||     |..|.|:..        || ..:::||..:. .....:..|...|.|.   .|. .
Human   131 ADIFHLANLTGLPPKDRDGHRAAGLRYP-EPDMVDILNRT-GHQLADMLKSCNFSGH---HCSAS 190

  Fly   162 IFKFHVTEMGYCFLANNLLDYDSIEEMPLRYSSLDNNRSLRL------YM---RSSVMYKYE--- 214
            .|....|..|.|:..|    .|....:|.|...:.:...:.|      |:   |.:....:|
Human   191 NFSVVYTRYGKCYTFN----ADPRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGI 251

  Fly   215 -MYVNSPEDLPFFNSLTYTISTDPTTYAFNVEEIHNHEGVIDEPISQRKCKFPS---ESSIEGF- 274
             :.::|.|:.|:.:.|.:.:|....|:....|:...:   :.:|..  .|:..|   |..::|:
Human   252 RVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTY---LPQPWG--NCRAESELREPELQGYS 311

  Fly   275 PYSFSACMSIIRSEFEMKTCDCSLFNPKDRNESLYCGLQHADCLIKEGFATRVKEYVGSSTVCLP 339
            .||.|||......|..::.|.|                             |:....|:.|:|.|
Human   312 AYSVSACRLRCEKEAVLQRCHC-----------------------------RMVHMPGNETICPP 347

  Fly   340 S----CVEQQISLVGVITE---------NGTLYNNNTQITEIQIASPPTVRY-ERKVTQTK---- 386
            :    |.:..:..:|...|         |.|.|..  :|:.::|.:..:.|| .||..:.:
Human   348 NIYIECADHTLDSLGGGPEGPCFCPTPCNLTRYGK--EISMVRIPNRGSARYLARKYNRNETYIR 410

  Fly   387 -----LD---------------------LIVGIGSVAGLFFGASLLNLLEIISY 414
                 ||                     |:..:|...|||.|||:|.||||:.|
Human   411 ENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDY 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk29	NP_001097442.2	ASC	123..415	CDD:279230	73/362 (20%)
ASIC4	NP_061144.4	ASC	40..488	CDD:413546	87/444 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152201
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850