Protein Alignment ppk29 and ASIC1

DIOPT Version :10

• Sequence 1: NP_001097442.2
• Gene: ppk29 / 37844
• FlyBaseID: FBgn0034965
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 469
• Identity: 87/469 - (18%)
• Similarity: 163/469 - (34%)
• Gaps: 159/469 - (33%)

  Fly    65 TFPSIGIC---------LTKSRAFN--EFKAMMREYFQEDFAFSFTRMIYEYAFLNPNNIFTKEP 118
            |||::.:|         ::|:..::  |..|::...::    ...|:|..|...    .|...:.
Human    86 TFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYE----IPDTQMADEKQL----EILQDKA 142

  Fly   119 TKNTSYPYNFNIL--------DIRRKMFPTNCTECFKEIYFRGELVTDCEEIFKFHVTEMGYCFL 175
            ...:..|..||:.        |||..:.  :|       :||||:.:  .|.||...|..|.|:.
Human   143 NFRSFKPKPFNMREFYDRAGHDIRDMLL--SC-------HFRGEVCS--AEDFKVVFTRYGKCYT 196

  Fly   176 ANN---------------------LLDYDSIEEMPLRYSSLDNNRSLRLYMRSSVMYKYEMYVNS 219
            .|:                     :||....|.:|: :...|         .:|.....::.::|
Human   197 FNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPV-WGETD---------ETSFEAGIKVQIHS 251

  Fly   220 PEDLPFFNSLTYTISTDPTTYAFNVEEIHNHEGVIDEPISQRKCK-FPSESSIEGF-PYSFSACM 282
            .::.||.:.|.:.::....|:....|     :.:|..|.....|| ...:|.::.| .||.:||.
Human   252 QDEPPFIDQLGFGVAPGFQTFVACQE-----QRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACR 311

  Fly   283 SIIRSEFEMKTCDCSLFN-PKDRNESLYC-GLQHADC-------LIKEGFATRVKEYVGSSTVCL 338
            ....:.:.::.|:|.:.: |.|   :.|| ..|:.:|       |:::.     :||......|.
Human   312 IDCETRYLVENCNCRMVHMPGD---APYCTPEQYKECADPALDFLVEKD-----QEYCVCEMPCN 368

  Fly   339 PSCVEQQISLVGVITENGTLY------------NNNTQITEIQIASPPTVRYERKVTQTKLDLIV 391
            .:...:::|:|.:.::....|            ..|..:.:|..   ..:.|| .:.|.|...|.
Human   369 LTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFF---EVLNYE-TIEQKKAYEIA 429

  Fly   392 G--------------------------------------------------IGSVAGLFFGASLL 406
            |                                                  ||...|||.|||:|
Human   430 GLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGASIL 494

  Fly   407 NLLEIISYFIKKLK 420
            .:||:..|..:.:|
Human   495 TVLELFDYAYEVIK 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk29	NP_001097442.2	ASC	8..415	CDD:459966	85/462 (18%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	87/469 (19%)