DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk29 and asic4a

DIOPT Version :9

Sequence 1:	NP_001097442.2	Gene:	ppk29 / 37844	FlyBaseID:	FBgn0034965	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_999952.1	Gene:	asic4a / 407668	ZFINID:	ZDB-GENE-040513-5	Length:	539	Species:	Danio rerio

Alignment Length:	454	Identity:	99/454 - (21%)
Similarity:	167/454 - (36%)	Gaps:	95/454 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GLLWIFVIGISG-----WSTVSILVLLKTRYETDSTTIGV-----STAYSRWIN---TFPSIGIC 72
            |:..|||.|..|     |:...::.|....|:.....|..     .||.:....   .||::.||
Zfish    52 GINHIFVSGRLGVRQTLWALAFLVSLALFLYQAAKCAISYLEHPHVTALNEEATPEMVFPAVTIC 116

  Fly    73 LTKSRAFNEFKAMMREYFQEDFAFSFTRMIYEYAFLN---PNNIFTKEPTKNTSYPYNFNILDIR 134
                 ..|.|:          |:......||..|.|.   |.|....:|| :..||.. ::.||.
Zfish   117 -----NINRFR----------FSALTDADIYHLANLTGLPPKNKDGHKPT-DLEYPAP-DMQDIF 164

  Fly   135 RKMFPTNCTECFKEIYFRGELVTDCE-EIFKFHVTEMGYCFLANN-------------------L 179
            .:. .....|..|...|.|:   :|. |.|....|..|.|:..|.                   :
Zfish   165 NRT-GHQLEEMLKSCNFSGQ---NCSAEDFTVVYTRYGKCYTFNGNKTTSRKTKQGGMGNGLEIM 225

  Fly   180 LDYDSIEEMPLRYSSLDNNRSLRLYMRSSVMYKYEMYVNSPEDLPFFNSLTYTISTDPTTYAFNV 244
            ||....:.:|:...:  |..||...:|        :.::|.::.|:.:.|.:.:|....|:....
Zfish   226 LDIQQDDYLPIWKET--NETSLEAGIR--------VQIHSQDEPPYIHQLGFGVSPGFQTFVSCQ 280

  Fly   245 EEIHNHEGVIDEPISQRKCKFPSESSIEGF-PYSFSACMSIIRSEFEMKTCDCSLFN-PKDRNES 307
            |:...:   :.:|..  .|:..||..|.|: .||.|||.....:...::.|.|.:.: |.|.|
Zfish   281 EQRLTY---LPQPWG--NCRSTSEQMIPGYDTYSISACRLRCETLEVLRECKCRMVHMPGDAN-- 338

  Fly   308 LYCGLQHADCLIKEGFATRVKEYVGSSTVCLPSC----VEQQISLVGVITENGTLY--------- 359
             .|......|:.|.  ...:::..|.:..|...|    ..:::|:|.:.::....|
Zfish   339 -ICTPSDIKCVDKA--LALLQKSSGDTCFCETPCNLTRYGKELSMVKIPSKGSARYLSRKYDKSE 400

  Fly   360 ---NNNTQITEIQIASPPTVRYERKVTQTKLDLIVGIGSVAGLFFGASLLNLLEIISYFIKKLK 420
               .:|..:.:|...:......|:|.......|:..||...|||.|||:|.:|||:.|..:.:|
Zfish   401 DYIRDNFLVLDIFFEALNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDYVYEVIK 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk29	NP_001097442.2	ASC	123..415	CDD:279230	70/329 (21%)
asic4a	NP_999952.1	ASC	44..472	CDD:295594	99/454 (22%)
asic4a	NP_999952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850