DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk29 and asic4b

DIOPT Version :9

Sequence 1:	NP_001097442.2	Gene:	ppk29 / 37844	FlyBaseID:	FBgn0034965	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_999951.1	Gene:	asic4b / 407667	ZFINID:	ZDB-GENE-040513-6	Length:	558	Species:	Danio rerio

Alignment Length:	451	Identity:	101/451 - (22%)
Similarity:	165/451 - (36%)	Gaps:	101/451 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GLLWIFVIGI----SGWSTVSILV---LLKTRYETDSTTIGVSTAYSRWINTFPSIGICLTKSRA 78
            ||..:..:|:    :.||..:.|.   |...|.||            |...|||:|.:|     .
Zfish    74 GLALLVSLGLFLYQATWSAATYLERPHLAALREET------------RRELTFPAITLC-----N 121

  Fly    79 FNEFKAMMREYFQEDFAFSFTRMIYEYAFLN---PNNIFTKEPTKNTSYPYNFNILDIRRKMFPT 140
            .|.|:          |:......||..|.|.   |.:.....|:: ..||.. |:|||.::. ..
Zfish   122 VNRFR----------FSALTDADIYHLANLTGLPPKSRKGHRPSE-LQYPPP-NMLDIFQRT-GH 173

  Fly   141 NCTECFKEIYFRGELVTDC-EEIFKFHVTEMGYCFLANN-------------------LLDYDSI 185
            ...:..|...|.|:   :| .|.|....|..|.|:..|.                   :||....
Zfish   174 QLEDMLKSCNFSGQ---NCSSEDFSVVYTRYGKCYTFNGNKTSPKRVRQGGTGNGLEMMLDIQQD 235

  Fly   186 EEMPLRYSSLDNNRSLRLYMRSSVMYKYEMYVNSPEDLPFFNSLTYTISTDPTTYAFNVEEIHNH 250
            |.:|:...:  |..:|...:|        :.::|..:.|:.:.|.:.:|....|:....|:...:
Zfish   236 EYLPIWRET--NETTLEAGIR--------VQIHSQNEPPYIHQLGFGVSPGFQTFVSCQEQRLTY 290

  Fly   251 EGVIDEPISQRKCKFPSESSIEGF-PYSFSACMSIIRSEFEMKTCDCSLFN-PKDRNESLYCGLQ 313
               :.:|..  .|:..||..|.|: .||.|||.....|....:.|:|.:.: |.|.:   .|...
Zfish   291 ---LPQPWG--NCRASSEPVIPGYDTYSVSACRLHCESTQVQRECNCRMVHMPGDAD---ICAPS 347

  Fly   314 HADCLIKEGFATRVKEYVGSSTVCLPSC----VEQQISLVGVITENGTLY------------NNN 362
            ...|:.|.  ...:::..|.|..|...|    ..:::|:|.:.:.....|            .:|
Zfish   348 KIKCVDKA--LASLQKSTGDSCPCETPCNLTRYGKELSMVKIPSRGSARYLSRKYQKSEEYIRDN 410

  Fly   363 TQITEIQIASPPTVRYERKVTQTKLDLIVGIGSVAGLFFGASLLNLLEIISYFIKKLKTMI 423
            ..|.:|...:......|:|.......|:..||...|||.|||:|.:|||:.|..:..|..|
Zfish   411 FLILDIFFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYIYEVAKNKI 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk29	NP_001097442.2	ASC	123..415	CDD:279230	73/329 (22%)
asic4b	NP_999951.1	ASC	54..497	CDD:295594	101/451 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586661
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850