Protein Alignment ppk29 and ASIC2

DIOPT Version :9

• Sequence 1: NP_001097442.2
• Gene: ppk29 / 37844
• FlyBaseID: FBgn0034965
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 95/484 - (19%)
• Similarity: 169/484 - (34%)
• Gaps: 147/484 - (30%)

  Fly    23 LWIFVIGIS-----GWSTVSILVLLKTRYETDSTTIGVSTAYSRWINTFPSIGICLTKSRAFNEF 82
            ||:.....|     .||:..:|..|.....|     .|...:||.: .||::.:|
Human    88 LWVLAFCTSFGLLLSWSSNRLLYWLSFPSHT-----RVHREWSRQL-PFPAVTVC---------- 136

  Fly    83 KAMMREYFQEDFAFSFTRM----IYEYA-----FLNPNNIFTKEPTKNTSYPYNFNIL---DIRR 135
                     .:....|.|:    :| ||     .|.||         .|:.|....:|   :.||
Human   137 ---------NNNPLRFPRLSKGDLY-YAGHWLGLLLPN---------RTARPLVSELLRGDEPRR 182

  Fly   136 KMF----------PTNCTECFKEIY----------------FRGELVTDC-EEIFKFHVTEMGYC 173
            :.|          |....|.....:                :||||   | ...|....|:.|.|
Human   183 QWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGEL---CGPHNFSSVFTKYGKC 244

  Fly   174 FLANN---------------------LLDYDSIEEMPLRYSSLDNNRSLRLYMRSSVMYKYEMYV 217
            ::.|:                     :||....|.:|:...:.:..      ..:.|    ::.:
Human   245 YMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETT------FEAGV----KVQI 299

  Fly   218 NSPEDLPFFNSLTYTISTDPTTYAFNVEEIHNHEGVIDEPISQRKCKFPSESSIEGFP-YSFSAC 281
            :|..:.||...|.:.::....|:....|:...:     .|....:|: .||..::.|| ||.:||
Human   300 HSQSEPPFIQELGFGVAPGFQTFVATQEQRLTY-----LPPPWGECR-SSEMGLDFFPVYSITAC 358

  Fly   282 MSIIRSEFEMKTCDCSLFN-PKDRNESLYC-GLQHADC------LIKEGFATRVKEYVGSSTVCL 338
            .....:.:.::.|:|.:.: |.|   :.:| ..||.:|      |:.|    :...|....|.|.
Human   359 RIDCETRYIVENCNCRMVHMPGD---APFCTPEQHKECAEPALGLLAE----KDSNYCLCRTPCN 416

  Fly   339 PSCVEQQISLVGVITENGTLY------------NNNTQITEIQIASPPTVRYERKVTQTKLDLIV 391
            .:...:::|:|.:.::....|            :.|..:.:|...:......|:|.......|:.
Human   417 LTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLG 481

  Fly   392 GIGSVAGLFFGASLLNLLEIISYFIKKLK 420
            .||...|||.|||:|.:||:..|..:.:|
Human   482 DIGGQMGLFIGASILTILELFDYIYELIK 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk29	NP_001097442.2	ASC	123..415	CDD:279230	70/363 (19%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	95/484 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152157
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850